Research Article

Targeted Proteomics of Isolated Glomeruli from the Kidneys of Diabetic Rats: Sorbin and SH3 Domain Containing 2 Is a Novel Protein Associated with Diabetic Nephropathy

Figure 1

Periodic acid Schiff (PAS) and immunohistochemical staining in the kidneys from OLETF (a, c, e, and g) and LETO (b, d, f, and h) rats at 27 and 38 weeks of age. Slight expansion of the mesangial matrix with mesangial cell proliferation (a). Normal glomeruli (b). Exudative and sclerotic lesion (c). Normal glomeruli (d). SORBS2 positivity in podocytes from OLETF rats (e, f) and negativity in those from LETO rats (f, h). Scale bar = 20 μm.
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