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Experimental Diabetes Research
Volume 2012, Article ID 108680, 5 pages
Research Article

Dynamic Aerobic Exercise Induces Baroreflex Improvement in Diabetic Rats

1Heart Institute (InCor), University of Sao Paulo Medical School, 05001-100 Sao Paulo, SP, Brazil
2Human Movement Laboratory, Sao Judas Tadeu University, 05001-100 Sao Paulo, SP, Brazil
3Laboratory of Translational Physiology, Nove de Julho University, Avenue Francisco Matarazzo, 612, Pós Graduação, No.1 andar, 05001-100 Sao Paulo, SP, Brazil

Received 23 August 2011; Accepted 30 October 2011

Academic Editor: Mariana Morris

Copyright © 2012 Luciana Jorge et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The objective of the present study was to investigate the effects of an acute aerobic exercise on arterial pressure (AP), heart rate (HR), and baroreflex sensitivity (BRS) in STZ-induced diabetic rats. Male Wistar rats were divided into control (n=8) and diabetic (n=8) groups. AP, HR, and BRS, which were measured by tachycardic and bradycardic (BR) responses to AP changes, were evaluated at rest (R) and postexercise session (PE) on a treadmill. At rest, STZ diabetes induced AP and HR reductions, associated with BR impairment. Attenuation in resting diabetes-induced AP (R: 103±2 versus PE: 111±3 mmHg) and HR (R: 290±7 versus PE: 328±10 bpm) reductions and BR dysfunction (R: -0.70±0.06 versus PE: -1.21±0.09 bpm/mmHg) was observed in the postexercise period. In conclusion, the hemodynamic and arterial baro-mediated control of circulation improvement in the postexercise period reinforces the role of exercise in the management of cardiovascular risk in diabetes.