Increased Inflammation in Atherosclerotic Lesions of Diabetic Akita-LDLr^−/− Mice Compared to Nondiabetic LDLr^−/− Mice

Figure 4

Male 𝐴𝑘𝑖𝑡𝑎-𝐿𝐷𝐿𝑟^−/− mice have increased inflammatory cytokines in plasma. Plasma samples from 24-week-old 𝐴𝑘𝑖𝑡𝑎-𝐿𝐷𝐿𝑟^−/− and 𝐿𝐷𝐿𝑟^−/− mice were analyzed for IL-1β (a), TNFα (b), or KC (c) using a multiplex assay. Values are presented as individual mice and as mean ± SEM. Two-way ANOVA revealed interactions between diabetes and gender ((a)*), and significant effect of diabetes ((a)*) and of gender ((a)**). Bonferroni post hoc test yielded **𝑃<0.01, ***𝑃<0.001. a and b: unpaired t-test.

(a)

(b)

(c)