Increased Inflammation in Atherosclerotic Lesions of Diabetic Akita-LDLr^−/− Mice Compared to Nondiabetic LDLr^−/− Mice

Table 1

Expression of inflammatory genes in the brachiocephalic artery of 18-week-old 𝐴𝑘𝑖𝑡𝑎-𝐿𝐷𝐿𝑟^−/− mice and 𝐿𝐷𝐿𝑟^−/− mice.

	IL-1𝛽	OPN	IL-6	VCAM	MMP-9	MCP-1	MIP2
Males
𝐴𝑘𝑖𝑡𝑎-𝐿𝐷𝐿𝑟^−/− (𝑛=6)	0.11±0.07	4.2±7.2	0.44±0.90	5.5±3.7	0.14±0.05	0.22±0.26	0.050±0.04
𝐿𝐷𝐿𝑟^−/− (𝑛=5)	0.09±0.12	3.4±6.6	1.1±2.1	6.8±4.1	0.10±0.05	0.20±0.24	0.059±0.05
Females
𝐴𝑘𝑖𝑡𝑎-𝐿𝐷𝐿𝑟^−/− (𝑛=5)	0.06±0.02	3.5±3.2	0.11±0.11	9.4±8.6	0.09±0.04	0.18±0.08	0.04±0.01^∗
𝐿𝐷𝐿𝑟^−/− (𝑛=4)	0.08±0.04	4.7±2.3	0.29±0.23	10.0±8.1	0.05±0.02	0.25±0.14	0.06±0.02

* 𝑃<0.05 versus 𝐿𝐷𝐿𝑟^−/− females; Mann-Whitney.
Levels of mRNA were measured by real-time RT-PCR and were normalized to the expression of the housekeeping control gene cyclophilin B. values represent mean ± SD.