Review Article

Animal Models of Diabetes Mellitus for Islet Transplantation

Table 1

Animal models of DM.

CharactersNameSpecies

Type 1 DM
 Spontaneous modelNODMouse
BBRat

Type 2 DM
ob/ob Mouse
db/db Mouse
 Obesity modelfa/fa Rat
Goto KakizakiRat
OLETFRat

Type 1 and 2 DM
 Drug-induced modelAlloxan *
STZ *

Pancreatic DM
 Pancreatomized modelPancreatectomy **

Others
Insulin knockoutMouse
 Transgenic animal modelIRS1 knockoutMouse
IRS2 knockoutMouse

All experimental animals are available.
**All experimental animals are available but larger animals tend to be used.