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Experimental Diabetes Research
Volume 2012, Article ID 309231, 7 pages
Research Article

The Effects of Green Tea Consumption on Cardiometabolic Alterations Induced by Experimental Diabetes

1Renal, Cardiovascular and Metabolic Physiopharmacology Laboratory, Health and Biological Science Center, Mackenzie University, 01302-907 São Paulo, Brazil
2School of Arts, Science and Humanities, University of Sao Paulo, Sao Paulo, Brazil

Received 8 September 2011; Revised 22 November 2011; Accepted 1 December 2011

Academic Editor: Mariana Morris

Copyright © 2012 Patricia Fiorino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We evaluated cardiac autonomic modulation by heart rate (HRV), and arterial pressure variability (APV), and metabolic response in streptozotocin diabetic rats treated with green tea. Male Wistar rats were separated in groups: control, drinking tap water (C), green tea-treated (GT) group, diabetic, drinking tap water (D), and diabetic, treated with green tea (DGT). Kidney mass was greater in D and DGT than in C and GT, but reduced in DGT compared to D. Green tea prevented the increase in creatinine clearance and reduced hyperglycemia in DGT compared to D. Arterial pressure was increased in GT and decreased in D compared to C. HRV was reduced in D compared with all groups. APV was decreased in D compared to C and recovery in DGT. Sympathetic modulation of APV was decreased in D compared with all groups. Green tea reduced hyperglycemia, prevented renal injury and autonomic dysfunction, suggesting reduced cardiovascular risk and target organ damage in diabetes.