Predictors of Impaired Glucose Regulation in Patients with Non-Alcoholic Fatty Liver Disease
Table 2
Glucose and insulin regulation in response to a 75 g oral glucose tolerance test in non-alcoholic fatty liver disease patients with and without hyperglycemia.
Patient characteristics
IFG/IGT,
DM,
Hyperglycemia (IFG/IGT or DM),
Normoglycemia,
value (patients with hyperglycemia versus normoglycemia)
Mean ± standard deviation
Glucose 0 min, mg/dL
89.9 ± 14.1
104.0 ± 21.9
95.4 ± 18.7
80.9 ± 10.5
<0.01
Insulin 0 min, μIU/mL
15.4 ± 8.3
19.5 ± 10.2
17.0 ± 9.3
13.8 ± 7.2
0.02
Glucose 30 min, mg/dL
160.4 ± 27.0
179.9 ± 42.1
167.7 ± 34.6
147.8 ± 32.5
<0.01
Insulin 30 min, μIU/mL
79.5 ± 53.4
65.3 ± 42.3
74.2 ± 49.7
94.5 ± 53.9
0.02
Glucose 60 min, mg/dL
204.5 ± 34.9
241.7 ± 40.3
219.1 ± 41.1
152.9 ± 39.0
<0.01
Insulin 60 min, μIU/mL
133.1 ± 72.0
112.4 ± 70.7
125.0 ± 71.7
136.7 ± 88.8
0.38
Glucose 90 min, mg/dL
196.9 ± 37.4
264.1 ± 38.9
219.8 ± 49.4
126.9 ± 32.9
<0.01
Insulin 90 min, μIU/mL
163.6 ± 80.0
183.0 ± 95.1
170.1 ± 84.6
122.9 ± 97.7
0.01
Glucose 120 min, mg/dL
163.2 ± 24.2
243.6 ± 38.3
194.7 ± 49.8
105.4 ± 21.7
<0.01
Insulin 120 min, μIU/mL
160.9 ± 96.3
168.8 ± 110.1
164.0 ± 101.2
85.3 ± 61.9
<0.01
Net incremental insulin AUC, μIU/mL * min
11872.9 ± 6608.2
10545.7 ± 6688.5
11352.8 ± 6626.1
10285.4 ± 6690.6
0.33
HOMA2-IR index
1.9 ± 1.0
2.5 ± 1.3
2.2 ± 1.2
1.7 ± 0.9
<0.01
AUC: area under the curve, HOMA2-IR: homeostasis model assessment of insulin resistance, DM: type 2 diabetes mellitus, IFG: impaired fasting glucose, IGT: impaired glucose tolerance, and LDL-C: low-density lipoprotein cholesterol.
