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Experimental Diabetes Research
Volume 2012, Article ID 386524, 6 pages
http://dx.doi.org/10.1155/2012/386524
Research Article

Adipocytokine Levels in Genetically High Risk for Type 2 Diabetes in the Indian Population: A Cross-Sectional Study

1Department of Biochemistry, L.N. Medical College, Kolar Road, Bema Kunj, Bhopal 462042, India
2Department of Medicine, L.N. Medical College and Research Centre, Kolar Road, Bhopal, Madhya Pradesh, India

Received 6 September 2012; Revised 18 October 2012; Accepted 18 October 2012

Academic Editor: Giuseppe Paolisso

Copyright © 2012 K. Subhash Chandra Bose et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. In view of the noteworthy role of adipocytokines in the onset of insulin resistance and diabetes in gene-knockout-rat-model-cell-line studies we aimed to study the influence of genetic predisposition for diabetes on adipocytokine levels and their role in building insulin-resistance-like environment well before the onset of diabetes; thus a hypothesis can be drawn on their role in developing diabetes in high risk population. Methods. Ages between 18 and 22 years were selected and divided into three groups. Group I : control group with no family history of diabetes. Group II : with one of their parents with history of type 2 diabetes. Group III : with both parents having history of type 2 diabetes. In all the groups we estimated fasting plasma glucose, insulin and adipocytokines like adiponectin, leptin, TNF-α, and IL-6. Results. Of all adipocytokines we observed significantly lower levels of adiponectin (μg/mL in group III and μg/mL group II) when compared to control (μg/mL; and it has strong correlation with family history of diabetes with Pearson’s coefficient of −0.502. Linear regression analysis showed significant negative association with HOMA-IR and logistic regression analysis showed highest association with parental diabetes (; OR .260, 95% CI .260–.468). Conclusion. Genetic predisposition for diabetes may influence adiponectin gene expression leading to decrease in its plasma concentration, which might play a key role in developing diabetes in near future.