𝟓HT_𝟐A and 𝟓HT_𝟐B Receptors Contribute to Serotonin-Induced Vascular Dysfunction in Diabetes

Table 2

Negative log EC₅₀ values [M] for serotonin receptor agonists in arteries from non-diabetic and diabetic mice.

Agonist	Non-diabetic	𝑛	Diabetic	𝑛
5HT	6.61 ± 0.14	17	6.96 ± 0.09	14
α-Methyl-5HT	6.33 ± 0.24	11	7.21 ± 0.17*	12
TCB-2	ND	6	7.78 ± 0.28	6
BRL54443	ND	11	6.54 ± 0.11	18
Norfenfluramine	5.39 ± 0.29	21	6.20 ± 0.05*	29
BW723C86	ND	6	5.73 ± 0.13	12

Mean ± SEM, ND: not determined, *𝑃<0.05 versus non-diabetic.