Correlation between Blood Activin Levels and Clinical Parameters of Type 2 Diabetes

Table 3

Associations between circulating levels of activin B and demographic and biochemical indices within subject groups.

	Total subjects	Normal	IFG/IGT	T2D
Age	0.100	−0.206	0.267	0.159
BMI	0.170	0.092	0.321	0.201
Smoking	0.160	0.029	0.356	0.200
Fasting glucose	0.298^**,†	0.072	0.080	0.406*
HbA1c	0.331^**,†	−0.193	0.292	0.529**
Fasting insulin	0.254*	0.051	0.510*	0.293
HOMA-IR	0.332^**,†	0.056	0.514*	0.426^*,†
AUCg	−0.100	0.066	−0.155	−0.274
Crcl	0.009	0.098	−0.121	0.004
HsCRP	0.120	0.021	−0.243	−0.119
Follistatin	0.026	0.008	−0.010	0.033

BMI: body mass index; HbA1c: glycated hemoglobin; HOMA-IR: homeostasis model assessment of insulin resistance; AUCg: area under the curve for OGTT glucose levels; Crcl: creatinine clearance; HsCRP: human sensitive C-reactive protein. Data presented as univariate Pearson correlation coefficients (𝑅) value: *𝑃<0.05, **𝑃<0.01. Correlations with no superscript are not significant (𝑃>0.05). ^†After adjustment for confounding factors (including age, BMI, history of smoking, history of hypertension and medication use, blood pressure parameters) by multivariate analysis, activin B retained a positive association among total subjects with fasting glucose, HbA1c, and HOMA-IR but lost its correlation with fasting insulin. In the T2D group, only HOMA-IR retained a positive correlation with activin A after adjustment.