Research Article

Dysregulation of Dicer1 in Beta Cells Impairs Islet Architecture and Glucose Metabolism

Figure 3

Dysregulated membranal E-Cadherin expression in Dicer1 mutant cells. Representative Control (RIP-Cre; Dicer1LoxP/+, (a)) and Mutant (RIP-Cre; Dicer1LoxP/LoxP, (b)) P11 islets, immunostained for E-Cadherin (white), and YFP (green) were taken for quantitative analysis. Magnified field in inset. Comparable E-Cadherin expression in YFP-negative cells in Mutant and Control animals (c). The incidence of Dicer1 mutant beta cells exhibiting dysregulated E-Cadherin expression is higher than in control beta cells, which do not express YFP, in the same islet (d). Bar −50 μm. * 𝑃 < 0 . 0 1 .
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