A PEDF-Derived Peptide Inhibits Retinal Neovascularization and Blocks Mobilization of Bone Marrow-Derived Endothelial Progenitor Cells

Figure 7

PEDF-34 reduces the number of circulating endothelial cells and EPCs in OIR mice. In the OIR model, Tie2-GFP pups received a daily i.p. injection of either PEDF-34, BSA, or a control peptide in PBS at a dose of 5 mg/kg of body weight from P12 to P16. At P16, Tie2-GFP⁺ circulating endothelial cells and EPCs in peripheral blood were quantified by FACS. The graph represents the percentage of Tie2-GFP⁺ cells in peripheral blood, based on 100% being set to the average number of Tie2-GFP⁺ cells from OIR mice injected with BSA alone.