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Experimental Diabetes Research
Volume 2012, Article ID 518426, 11 pages
http://dx.doi.org/10.1155/2012/518426
Research Article

A PEDF-Derived Peptide Inhibits Retinal Neovascularization and Blocks Mobilization of Bone Marrow-Derived Endothelial Progenitor Cells

1Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma, OK 73104, USA
2Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma, OK 73104, USA

Received 1 April 2011; Accepted 27 April 2011

Academic Editor: Gian Paolo Fadini

Copyright © 2012 Richard Longeras et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The supplementary material includes two supplementary figures:

Supplementary Figure 1 provides data that demonstrates that PEDF-34 does not alter the number of Tie2-GFP+ cells in the bone marrow of OIR mice at P16. This shows that PEDF-34 specifically reduces the level of circulating endothelial cells and EPCs in the peripheral blood during OIR.

Supplementary Figure 2 shows that PEDF-34 does not alter VEGF plasma levels in OIR mice. This demonstrates that PEDF-34 functions in the presence of VEGF to reduce circulating endothelial cells and EPCs during OIR.

  1. Supplementary Figure 1
  2. Supplementary Figure 2