Mannan-Binding Lectin in Diabetic Kidney Disease: The Impact of Mouse Genetics in a Type 1 Diabetes Model
Figure 4
Creatinine clearance. Creatinine clearance by mouse strain: WT, diabetes WT (d-WT), MBL-KO (KO), and diabetes MBL-KO (d-KO). (a) C57BL/6JBomTac animals with median indicated by “♦” (median presented as data could not be fitted to normality). (b) 129S6/SvEvTac animals with “♦” indicating the mean. In 129S6/SvEvTac animals, creatinine clearance could not be estimated in two animals because of technical issues (both control MBL-KO animals) and in two animals because of lost serum (one control MBL-KO animal and one diabetic MBL-KO animal). No statistical significance was found on interaction between MBL and diabetic effects, or on diabetic change, or on impact of MBL deficiency.
