Research Article

Mannan-Binding Lectin in Diabetic Kidney Disease: The Impact of Mouse Genetics in a Type 1 Diabetes Model

Table 1

Body weight and blood glucose.

GroupANOVA
StrainWTd-WTKOd-KO

Body weight (g)C57BL/6JBomTac, start21.1 (19.8;22.5)20.8 (19.4;22.2)19.6 (18.0;21.2)20.7 (19.1;22.3)NSNSNS
C57BL/6JBomTac, end25.3 (24.2;26.4)22.4 (21.3;23.5)25.3 (24.0;26.6)22.2 (20.9;23.5)NS<0.001NS
129S6/SvEvTac, start20.9 (19.5;22.6)20.6 (19.4;21.8)18.2 (16.8;19.5)17.7 (16.5;19.0)NSNS<0.001
129S6/SvEvTac, end25.7 (23.7;27.7)23.7 (21.8;25.5)22.4 (20.3;24.4)20.8 (18.9;22.6)NS0.060.003

Student’s t-test

Blood glucose (mmol/L)C57BL/6JBomTac, start6.3 (5.4;7.3)5.9 (4.9;6.8)6.1 (4.9;7.2)7.5 (6.4;8.7)NS0.03
C57BL/6JBomTac, end6.0 (2.8;9.2)20.7 (17.5;23.9)6.2 (2.4;10.0)22.0 (18.2;25.7)NSNS
C57BL/6JBomTac, area under the curveNS
129S6/SvEvTac, start6.2 (5.3;7.0)6.8 (6.1;7.6)6.3 (5.5;7.1)7.2 (6.4;7.9)NSNS
129S6/SvEvTac, end6.2 (4.3;8.2)20.4 (18.6;22.2)6.4 (4.5;8.3)16.8 (15.0;18.6)NS0.007
129S6/SvEvTac, area under the curveNS

Body weight and blood glucose by strain at start and end of study in wild-type (WT), diabetes WT (d-WT), MBL knockout (KO), and diabetes KO (d-KO).
Values indicate mean (95% confidence interval).
Comparisons were made with ANOVA (body weight) and Student’s t-test (blood glucose).
: interaction between diabetes and MBL.
: diabetic versus nondiabetic animals.
: MBL knockout versus WT animals.
: wild-type versus knockout.
: diabetic wild-type versus diabetic knockout; NS: P > 0.05.