Mannan-Binding Lectin in Diabetic Kidney Disease: The Impact of Mouse Genetics in a Type 1 Diabetes Model
Table 1
Body weight and blood glucose.
Group
ANOVA
Strain
WT
d-WT
KO
d-KO
Body weight (g)
C57BL/6JBomTac, start
21.1 (19.8;22.5)
20.8 (19.4;22.2)
19.6 (18.0;21.2)
20.7 (19.1;22.3)
NS
NS
NS
C57BL/6JBomTac, end
25.3 (24.2;26.4)
22.4 (21.3;23.5)
25.3 (24.0;26.6)
22.2 (20.9;23.5)
NS
<0.001
NS
129S6/SvEvTac, start
20.9 (19.5;22.6)
20.6 (19.4;21.8)
18.2 (16.8;19.5)
17.7 (16.5;19.0)
NS
NS
<0.001
129S6/SvEvTac, end
25.7 (23.7;27.7)
23.7 (21.8;25.5)
22.4 (20.3;24.4)
20.8 (18.9;22.6)
NS
0.06
0.003
Student’s t-test
Blood glucose (mmol/L)
C57BL/6JBomTac, start
6.3 (5.4;7.3)
5.9 (4.9;6.8)
6.1 (4.9;7.2)
7.5 (6.4;8.7)
NS
0.03
C57BL/6JBomTac, end
6.0 (2.8;9.2)
20.7 (17.5;23.9)
6.2 (2.4;10.0)
22.0 (18.2;25.7)
NS
NS
C57BL/6JBomTac, area under the curve
NS
129S6/SvEvTac, start
6.2 (5.3;7.0)
6.8 (6.1;7.6)
6.3 (5.5;7.1)
7.2 (6.4;7.9)
NS
NS
129S6/SvEvTac, end
6.2 (4.3;8.2)
20.4 (18.6;22.2)
6.4 (4.5;8.3)
16.8 (15.0;18.6)
NS
0.007
129S6/SvEvTac, area under the curve
NS
Body weight and blood glucose by strain at start and end of study in wild-type (WT), diabetes WT (d-WT), MBL knockout (KO), and diabetes KO (d-KO). Values indicate mean (95% confidence interval). Comparisons were made with ANOVA (body weight) and Student’s t-test (blood glucose). : interaction between diabetes and MBL. : diabetic versus nondiabetic animals. : MBL knockout versus WT animals. : wild-type versus knockout. : diabetic wild-type versus diabetic knockout; NS: P > 0.05.