Journal of Diabetes Research / 2012 / Article / Tab 4

Research Article

Angiotensin-Converting Enzyme Genotype and Peripheral Arterial Disease in Diabetic Patients

Table 4

Gene-environment models evaluating the interaction between insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) genotypes and traditional risk factors including hypertension, smoking, and dyslipidemia in peripheral arterial disease.

Risk factorACE genotypeTotal Peripheral arterial
disease, (%)
Adjusted odds ratio
(95% confidence interval)
-valueSynergy index of multiplicativitySynergy index
of additivity
NoYes

Hypertension
 NoII/ID349334151.001.23 (0.19–8.01)2.01 (0.32–12.8)
DD373522.10 (0.40–11.17)0.383
 YesII/ID508454542.09 (1.07–4.07)0.030
DD5141105.41 (2.05–14.31)0.001

Smoking
Never smokersII/ID553510431.001.21 (0.25–5.87)2.16 (0.43–10.80)
DD585082.33 (0.94–5.81)0.069
Ever smokersII/ID303277262.63 (1.16–5.96)0.021
DD302647.38 (1.87–29.06)0.004

Dyslipidemia
 NoII/ID299284151.001.21 (0.23–6.37)1.88 (0.29–12.04)
DD353232.16 (0.53–8.90)0.285
 YesII/ID558504541.77 (0.92–3.43)0.088
DD534494.64 (1.70–12.64)0.003

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