Table of Contents Author Guidelines Submit a Manuscript
Experimental Diabetes Research
Volume 2012, Article ID 702948, 10 pages
http://dx.doi.org/10.1155/2012/702948
Research Article

Effect of Exercise on Kidney Function, Oxidative Stress, and Inflammation in Type 2 Diabetic KK-Ay Mice

Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan

Received 28 March 2012; Revised 17 May 2012; Accepted 4 June 2012

Academic Editor: Mark Emmanuel Cooper

Copyright © 2012 Yuji Ishikawa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Gorin, K. Block, J. Hernandez et al., “Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney,” Journal of Biological Chemistry, vol. 280, no. 47, pp. 39616–39626, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. A. A. Eid, Y. Gorin, B. M. Fagg et al., “Mechanisms of podocyte injury in diabetes role of cytochrome P450 and NADPH oxidases,” Diabetes, vol. 58, no. 5, pp. 1201–1211, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. D. K. Singh, P. Winocour, and K. Farrington, “Oxidative stress in early diabetic nephropathy: fueling the fire,” Nature Reviews Endocrinology, vol. 7, no. 3, pp. 176–184, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Fornoni, A. Ijaz, T. Tejada, and O. Lenz, “Role of inflammation in diabetic nephropathy,” Current Diabetes Reviews, vol. 4, no. 1, pp. 10–17, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Hagiwara, Y. Makita, L. Gu et al., “Eicosapentaenoic acid ameliorates diabetic nephropathy of type 2 diabetic KKAy/Ta mice: involvement of MCP-1 suppression and decreased ERK1/2 and p38 phosphorylation,” Nephrology Dialysis Transplantation, vol. 21, no. 3, pp. 605–615, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. I. Ohara, M. Tanimoto, T. Gohda et al., “Effect of combination therapy with angiotensin receptor blocker and 1,25-dihydroxyvitamin D3 in type 2 diabetic nephropathy in KK-Ay/Ta mice,” Nephron. Experimental Nephrology, vol. 117, no. 4, pp. e124–e132, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Matsumoto, M. Tanimoto, T. Gohda et al., “Effect of pitavastatin on type 2 diabetes mellitus nephropathy in KK-Ay/Ta mice,” Metabolism, vol. 57, no. 5, pp. 691–697, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Susztak, A. C. Raff, M. Schiffer, and E. P. Böttinger, “Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy,” Diabetes, vol. 55, no. 1, pp. 225–233, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. K. H. Koh, B. Dayanath, and J. C. Doery, “Effect of exercise on albuminuria in people with diabetes,” Nephrology, vol. 16, no. 8, pp. 704–709, 2011. View at Google Scholar
  10. G. Fuiano, D. Mancuso, P. Cianfrone et al., “Can young adult patients with proteinuric IgA nephropathy perform physical exercise?” American Journal of Kidney Diseases, vol. 44, no. 2, pp. 257–263, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. I. Eidemak, “Exercise training and the progression of chronic renal failure,” Nephron, vol. 75, no. 1, pp. 36–40, 1997. View at Google Scholar · View at Scopus
  12. S. Ghosh, M. Khazaei, F. Moien-Afshari et al., “Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice,” American Journal of Physiology, vol. 296, no. 4, pp. F700–F708, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. J. M. Chiasera, K. M. Ward-Cook, S. A. McCune, and G. M. Wardlaw, “Effect of aerobic training on diabetic nephropathy in a rat model of type 2 diabetes mellitus,” Annals of Clinical and Laboratory Science, vol. 30, no. 4, pp. 346–353, 2000. View at Google Scholar · View at Scopus
  14. K. M. Ward, J. D. Mahan, and W. M. Sherman, “Aerobic training and diabetic nephropathy in the obese Zucker rat,” Annals of Clinical and Laboratory Science, vol. 24, no. 3, pp. 266–277, 1994. View at Google Scholar · View at Scopus
  15. U. Pechter, M. Ots, S. Mesikepp et al., “Beneficial effects of water-based exercise in patients with chronic kidney disease,” International Journal of Rehabilitation Research, vol. 26, no. 2, pp. 153–156, 2003. View at Google Scholar · View at Scopus
  16. C. Kornhauser, J. M. Malacara, and M. H. Macias-Cervantes, “Effect of exercise intensity on albuminuria in adolescents with Type 1 diabetes mellitus,” Diabetic Medicine, vol. 29, no. 1, pp. 70–73, 2012. View at Google Scholar
  17. D. J. Leehey, I. Moinuddin, J. P. Bast et al., “Aerobic exercise in obese diabetic patients with chronic kidney disease: a randomized and controlled pilot study,” Cardiovascular Diabetology, vol. 8, article 62, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Fujita, T. Sakamoto, and K. Komatsu, “Reduction of circulating superoxide dismutase activity in type 2 diabetic patients with microalbuminuria and its modulation by telmisartan therapy,” Hypertension Research, vol. 34, no. 12, pp. 1302–1308, 2011. View at Google Scholar
  19. M. Nishimura, “Breeding of mice strains for diabetes mellitus,” Experimental Animals, vol. 18, pp. 147–157, 1969. View at Google Scholar
  20. T. Ito, M. Tanimoto, K. Yamada et al., “Glomerular changes in the KK-Ay/Ta mouse: a possible model for human type 2 diabetic nephropathy,” Nephrology, vol. 11, no. 1, pp. 29–35, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Tanimoto, T. Gohda, S. Kaneko et al., “Effect of pyridoxamine (K-163), an inhibitor of advanced glycation end products, on type 2 diabetic nephropathy in KK-Ay /Ta mice,” Metabolism, vol. 56, no. 2, pp. 160–167, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Zhang, S. Hagiwara, M. Matsumoto et al., “Effects of eicosapentaenoic acid on the early stage of type 2 diabetic nephropathy in KKAy/Ta mice: involvement of anti-inflammation and antioxidative stress,” Metabolism: Clinical and Experimental, vol. 55, no. 12, pp. 1590–1598, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Hagiwara, T. Gohda, M. Tanimoto et al., “Effects of pyridoxamine (K-163) on glucose intolerance and obesity in high-fat diet C57BL/6J mice,” Metabolism, vol. 58, no. 7, pp. 934–945, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. Q. Fan, J. Liao, M. Kobayashi et al., “Candesartan reduced advanced glycation end-products accumulation and diminished nitro-oxidative stress in type 2 diabetic KK/Ta mice,” Nephrology Dialysis Transplantation, vol. 19, no. 12, pp. 3012–3020, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. E. R. Weibel, Ed., Stereological Methods. Practical Methods for Biological Morphometry, vol. 1, Academic Press, London, UK, 1979.
  26. H. Huang, K. T. Iida, H. Sone, T. Yokoo, N. Yamada, and R. Ajisaka, “The effect of exercise training on adiponectin receptor expression in KKAy obese/diabetic mice,” Journal of Endocrinology, vol. 189, no. 3, pp. 643–653, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. P. Boor, P. Celec, M. Behuliak et al., “Regular moderate exercise reduces advanced glycation and ameliorates early diabetic nephropathy in obese Zucker rats,” Metabolism, vol. 58, no. 11, pp. 1669–1677, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. C. N. Lumeng, J. L. Bodzin, and A. R. Saltiel, “Obesity induces a phenotypic switch in adipose tissue macrophage polarization,” Journal of Clinical Investigation, vol. 117, no. 1, pp. 175–184, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. H. S. Park, J. Y. Park, and R. Yu, “Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6,” Diabetes Research and Clinical Practice, vol. 69, no. 1, pp. 29–35, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. F. Moien-Afshari, S. Ghosh, M. Khazaei, T. J. Kieffer, R. W. Brownsey, and I. Laher, “Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db mice,” Diabetologia, vol. 51, no. 7, pp. 1327–1337, 2008. View at Publisher · View at Google Scholar · View at Scopus