The Common C49620T Polymorphism in the Sulfonylurea Receptor Gene SUR1 (ABCC8) in Patients with Gestational Diabetes and Subsequent Glucose Metabolism Abnormalities

Table 1

Clinical characteristics of the study groups and glucose metabolism, beta-cell function, and insulin resistance in baseline conditions and during the oral glucose tolerance test.

	GDM (+)	GDM (−)
Parameter	Mean ± SD	Mean ± SD	P value
	(n = 199)	(n = 50)
Number of pregnancies	2.2 ± 2.8	1.9 ± 2.1	NS
Number of deliveries	1.88 ± 2.8	1.82 ± 2.4	NS
Average time since the GDM-complicated pregnancy (years)	7.4 ± 0.7	7.8 ± 1.0	NS
Age at the time of delivery (years)	30.8 ± 5.7	29.2 ± 6.1	NS
Age (years)	38.4 ± 6.6	36.8 ± 5.6	NS
Height (cm)	163.3 ± 5.9	164.2 ± 6.8	NS
Body weight (kg)	67.9 ± 15.2	68.7 ± 14.9	NS
BMI (kg/m^2)	25.5 ± 5.6	25.4 ± 5.0	NS
Waist circumference (cm)	84.8 ± 13.2	85.0 ± 13.4	NS
Hip circumference (cm)	98.5 ± 11.1	100.1 ± 10.7	NS
WHR	0.86 ± 0.09	0.84 ± 0.07	NS
Fat tissue mass (kg)	21.9 ± 10.2	22.6 ± 11.1	NS
% of fat tissue (%)	31.0 ± 8.0	31.2 ± 8.9	NS
Lean body mass (kg)	45.5 ± 6.1	46.1 ± 4.8	NS
Mean systolic blood pressure (mm Hg)	123.2 ± 17.3	118.8 ± 14.8	NS
Mean diastolic blood pressure (mm Hg)	81.4 ± 12.0	79.0 ± 9.9	NS
Heart rate (/min.)	78.9 ± 11.5	80.2 ± 10.8	NS
Glucose 0^′ (mmol/L)	5.3 ± 0.7	4.9 ± 0.6	<0.0001
Glucose 60^′ (mmol/L)	8.3 ± 2.6	5.8 ± 1.9	<0.0001
Glucose 120^′ (mmol/L)	6.4 ± 2.2	4.8 ± 1.1	<0.0001
Insulin 0^′ (𝜇IU/mL)	13.7 ± 8.7	13.7 ± 8.5	NS
Insulin 60^′ (𝜇IU/mL)	106.8 ± 62.6	83.8 ± 41.1	0.0204
Insulin 120^′ (𝜇IU/mL)	74.6 ± 58.7	47.5 ± 30.6	0.0013
HbA1c (%)	5.6 ± 0.4	5.4 ± 0.4	0.0083
HOMA IR	1.76 ± 1.05	1.73 ± 1.03	NS
HOMA %S	72.2 ± 38.5	69.7 ± 27.0	NS
HOMA %B	125.4 ± 52.7	145.7 ± 49.2	0.0012