Research Article
Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Diet-Induced Metabolic Syndrome in Rats
Table 1
Physiological parameters of CS-, HCHF-, CS +
t-AUCB-, HCHF +
t-AUCB-treated rats. *
versus CS-fed rats; **
versus HCHF-fed rats.
| | Parameter | CS (16 weeks) | HCHF (16 weeks) | CS + t-AUCB
(16 weeks) | HCHF + t-AUCB
(16 weeks) |
| | Body weight @ week 16 (g) | 422 ± 6
() | 515.8 ± 11.9
() | 415 ± 6
() | 515.7 ± 13
() | | Abdominal fat deposition (mg/mm tibial length) | 401 ± 56
() | 746 ± 67*
() | 270 ± 38
() | 674 ± 99*
() | | Total fat mass (g) | 56 ± 5
() | 139.4 ± 16*
() | 46.7 ± 8
() | 154.3 ± 19*
() | | Heart rate (bpm) | 249 ± 9
() | 251 ± 21
() | 262 ± 13
() | 265 ± 8
() | | LVIDd (mm) | 6.73 ± 0.2
() | 7.54 ± 0.18*
() | 6.8 ± 0.2**
() | 6.8 ± 0.2**
() | | LVPWd (mm) | 1.69 ± 0.1
() | 1.95 ± 0.1
() | 1.69 ± 0.08
() | 1.9 ± 0.1
() | | LVIDs (mm) | 3.9 ± 0.3
() | 4.9 ± 0.2*
() | 3.6 ± 0.2**
() | 4.2 ± 0.2**
() | | E/A ratio | 1.6 ± 0.1
() | 1.2 ± 0.1*
() | 2.0 ± 0.2**
() | 1.5 ± 0.04**
() | | Ejection fraction (%) | 79 ± 4
() | 72 ± 2
() | 85 ± 2**
() | 76 ± 3
() | | Cardiac output (mL/min) | 63.4 ± 6.4
() | 83.8 ± 9
() | 81.8 ± 10
() | 72.2 ± 7
() | | Estimated LV mass (g) | 0.74 ± 0.05
() | 1.0 ± 0.05*
() | 0.77 ± 0.05**
() | 0.84 ± 0.04**
() | | Diastolic stiffness constant (κ) | 20.5 ± 1.9
() | 28.9 ± 1*
() | 22.8 ± 0.4**
() | 20.1 ± 0.1**
() | | Plasma insulin concentrations | 2.2 ± 0.4
() | 4.2 ± 0.3*
() | 4.7 ± 1.1*
() | 5.2 ± 1*
() | | Plasma leptin concentrations | 6.8 ± 0.86
() | 8.6 ± 1.1
() | 6.9 ± 0.8
() | 9.7 ± 0.5
() | | Plasma ALT activity, U/L | 37 ± 0.6
() | 59.6 ± 0.3*
() | 52.3 ± 2*
() | 49.4 ± 3.2*
() | | Plasma AST activity, U/L | 73.2 ± 5.6
() | 105.3 ± 9*
() | 68.2 ± 3.2**
() | 69.7 ± 5.7**
() | | Plasma ALP activity, U/L | 174 ± 19
() | 251 ± 21*
() | 192 ± 11**
() | 274 ± 29*
() | | Plasma LDH activity, U/L | 204 ± 23
() | 497 ± 14*
() | 180 ± 56**
() | 184 ± 26**
() | | LV + septum (mg/mm tibial length) | 18.9 ± 0.9
() | 21.8 ± 1.1
() | 20.3 ± 1.5
() | 20.5 ± 0.8
() | | Right ventricle (mg/mm tibial length) | 4.14 ± 0.3
() | 4.48 ± 0.3
() | 3.7 ± 0.2
() | 4.4 ± 0.3
() | | Liver (mg/mm tibial length) | 234 ± 14
() | 287 ± 12*
() | 264 ± 15
() | 292 ± 19*
() | | Islets as % area of pancreas | 6.2 ± 1.4
() | 15.3 ± 1.5
() | 5.2 ± 0.1
() | 16.7 ± 1.3
() | | Number of α cells/islet | 16.9 ± 0.5
| 39.3 ± 1.2
| 22.4 ± 1.9
| 38.6 ± 1.4
() | | Number of β cells/islet | 72.3 ± 2.8
() | 124.7 ± 7.2
() | 117.1 ± 4.1
() | 149.8 ± 6.3
() |
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