Table of Contents Author Guidelines Submit a Manuscript
Experimental Diabetes Research
Volume 2012, Article ID 793783, 5 pages
http://dx.doi.org/10.1155/2012/793783
Research Article

Oxidative Metabolism Genes Are Not Responsive to Oxidative Stress in Rodent Beta Cell Lines

Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Barrack Road, Exeter EX2 5DW, UK

Received 21 October 2011; Revised 18 November 2011; Accepted 19 November 2011

Academic Editor: Dan Nemet

Copyright © 2012 Faer Morrison et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Cnop, “Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes,” Biochemical Society Transactions, vol. 36, no. 3, pp. 348–352, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. A. P. Robertson, “Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes,” Journal of Biological Chemistry, vol. 279, no. 41, pp. 42351–42354, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. Q. Kong and C. L. G. Lin, “Oxidative damage to RNA: mechanisms, consequences, and diseases,” Cellular and Molecular Life Sciences, vol. 67, no. 11, pp. 1817–1829, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Anello, R. Lupi, D. Spampinato et al., “Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients,” Diabetologia, vol. 48, no. 2, pp. 282–289, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. D. E. Kelley, J. He, E. V. Menshikova, and V. B. Ritov, “Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes,” Diabetes, vol. 51, no. 10, pp. 2944–2950, 2002. View at Google Scholar · View at Scopus
  6. M. E. Patti, A. J. Butte, S. Crunkhorn et al., “Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 14, pp. 8466–8471, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. V. K. Mootha, C. M. Lindgren, K. F. Eriksson et al., “PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes,” Nature Genetics, vol. 34, no. 3, pp. 267–273, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Misu, T. Takamura, N. Matsuzawa et al., “Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes,” Diabetologia, vol. 50, no. 2, pp. 268–277, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Lenzen, “Oxidative stress: the vulnerable β-cell,” Biochemical Society Transactions, vol. 36, no. 3, pp. 343–347, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Sakai, K. Matsumoto, T. Nishikawa et al., “Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic β-cells,” Biochemical and Biophysical Research Communications, vol. 300, no. 1, pp. 216–222, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. D. A. Cunha, P. Hekerman, L. Ladrière et al., “Initiation and execution of lipotoxic ER stress in pancreatic β-cells,” Journal of Cell Science, vol. 121, no. 14, pp. 2308–2318, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Mosmann, “Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays,” Journal of Immunological Methods, vol. 65, no. 1-2, pp. 55–63, 1983. View at Google Scholar · View at Scopus
  13. J. C. Florez, J. Hirschhorn, and D. Altshuler, “The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits,” Annual Review of Genomics and Human Genetics, vol. 4, pp. 257–291, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. G. A. Rutter, G. Da Silva Xavier, and I. Leclerc, “Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis,” Biochemical Journal, vol. 375, no. 1, pp. 1–16, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Kaneto, Y. Kajimoto, Y. Fujitani et al., “Oxidative stress induces p21 expression in pancreatic islet cells: possible implication in beta-cell dysfunction,” Diabetologia, vol. 42, no. 9, pp. 1093–1097, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Fujimoto and K. S. Polonsky, “Pdx1 and other factors that regulate pancreatic β-cell survival,” Diabetes, Obesity and Metabolism, vol. 11, no. 4, pp. 30–37, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Yamada and T. Noguchi, “Nutrient and hormonal regulation of pyruvate kinase gene expression,” Biochemical Journal, vol. 337, no. 1, pp. 1–11, 1999. View at Publisher · View at Google Scholar · View at Scopus
  18. N. Li, T. Brun, M. Cnop, D. A. Cunha, D. L. Eizirik, and P. Maechler, “Transient oxidative stress damages mitochondrial machinery inducing persistent β-cell dysfunction,” Journal of Biological Chemistry, vol. 284, no. 35, pp. 23602–23612, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Lin, A. H. Berg, P. Iyengar et al., “The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species,” Journal of Biological Chemistry, vol. 280, no. 6, pp. 4617–4626, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Gao, S. Nong, X. Huang et al., “The effects of palmitate on hepatic insulin resistance are mediated by NADPH oxidase 3-derived reactive oxygen species through JNK and p38 MAPK pathways,” Journal of Biological Chemistry, vol. 285, no. 39, pp. 29965–29973, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Lupi and S. Del Prato, “β-cell apoptosis in type 2 diabetes: quantitative and functional consequences,” Diabetes and Metabolism, vol. 34, no. 2, pp. S56–S64, 2008. View at Publisher · View at Google Scholar · View at Scopus