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Experimental Diabetes Research
Volume 2012 (2012), Article ID 829758, 11 pages
http://dx.doi.org/10.1155/2012/829758
Research Article

Ca+2/Calmodulin-Dependent Protein Kinase Mediates Glucose Toxicity-Induced Cardiomyocyte Contractile Dysfunction

1Department of Geriatrics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China
2Department of Physiology, The Fourth Military Medical University, Xi'an 710032, China
3Division of Pharmaceutical Sciences, University of Wyoming, College of Health Sciences, Laramie, WY 82071, USA

Received 22 March 2012; Accepted 29 March 2012

Academic Editor: Yingmei Zhang

Copyright © 2012 Rong-Huai Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Li, Y. Hua, and J. Ren, “Short-chain fatty acid propionate alleviates Akt2 knockout-induced myocardial contractile dysfunction,” Experimental Diabetes Research, vol. 2012, Article ID 851717, 2012. View at Publisher · View at Google Scholar
  2. W. H. Tang, W. T. Cheng, G. M. Kravtsov et al., “Cardiac contractile dysfunction during acute hyperglycemia due to impairment of SERCA by polyol pathway-mediated oxidative stress,” American Journal of Physiology, vol. 299, no. 3, pp. C643–C653, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. M. E. Cooper and A. El-Osta, “Epigenetics: mechanisms and implications for diabetic complications,” Circulation Research, vol. 107, no. 12, pp. 1403–1413, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Voulgari, D. Papadogiannis, and N. Tentolouris, “Diabetic cardiomyopathy: from the pathophysiology of the cardiac myocytes to current diagnosis and management strategies,” Vascular Health and Risk Management, vol. 6, pp. 883–903, 2010. View at Google Scholar · View at Scopus
  5. H. Ma, S. Y. Li, P. Xu et al., “Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) up-regulation contribute to the onset of diabetic cardiomyopathy,” Journal of Cellular and Molecular Medicine, vol. 13, no. 8, pp. 1751–1764, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Ren and A. F. Ceylan-Isik, “Diabetic cardiomyopathy: do women differ from men?” Endocrine, vol. 25, no. 2, pp. 73–83, 2004. View at Google Scholar · View at Scopus
  7. J. Ren, L. Pulakat, A. Whaley-Connell, and J. R. Sowers, “Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease,” Journal of Molecular Medicine, vol. 88, no. 10, pp. 993–1001, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. L. E. Wold, A. F. Ceylan-Isik, and J. Ren, “Oxidative stress and stress signaling: menace of diabetic cardiomyopathy,” Acta Pharmacologica Sinica, vol. 26, no. 8, pp. 908–917, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Nakamura, S. Matoba, E. Iwai-Kanai et al., “p53 Promotes cardiac dysfunction in diabetic mellitus caused by excessive mitochondrial respiration-mediated reactive oxygen species generation and lipid accumulation,” Circulation, vol. 5, no. 1, pp. 106–115, 2012. View at Google Scholar
  10. S. K. Kota, S. K. Kota, S. Jammula, S. Panda, and K. D. Modi, “Effect of diabetes on alteration of metabolism in cardiac myocytes: therapeutic implications,” Diabetes Technology & Therapeutics, vol. 13, no. 11, pp. 1155–1160, 2011. View at Publisher · View at Google Scholar
  11. Z. Xie, K. Lau, B. Eby et al., “Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice,” Diabetes, vol. 60, no. 6, pp. 1770–1778, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Ren, “Paradoxical effects of pyruvate on cardiac contractile function under normal and high glucose in ventricular myocytes,” Pharmacological Research, vol. 48, no. 1, pp. 25–29, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. K. T. Chambers, T. C. Leone, N. Sambandam et al., “Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response,” The Journal of Biological Chemistry, vol. 286, no. 13, pp. 11155–11162, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. S. K. Bhardwaj and G. Kaur, “Effect of diabetes on calcium/calmodulin dependent protein kinase-II from rat brain,” Neurochemistry International, vol. 35, no. 4, pp. 329–335, 1999. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Colomer and A. R. Means, “Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease,” Sub-Cellular Biochemistry, vol. 45, pp. 169–214, 2007. View at Google Scholar · View at Scopus
  16. W. Fan, X. Li, and N. G. Cooper, “CaMKIIalphaB mediates a survival response in retinal ganglion cells subjected to a glutamate stimulus,” Investigative Ophthalmology & Visual Science, vol. 48, no. 8, pp. 3854–3863, 2007. View at Google Scholar
  17. H. Takeda, Y. Kitaoka, Y. Hayashi et al., “Calcium/calmodulin-dependent protein kinase II regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity,” Brain Research, vol. 1184, no. 1, pp. 306–315, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Ren, L. J. Dominguez, J. R. Sowers, and A. J. Davidoff, “Troglitazone attenuates high-glucose-induced abnormalities in relaxation and intracellular calcium in rat ventricular myocytes,” Diabetes, vol. 45, no. 12, pp. 1822–1825, 1996. View at Google Scholar · View at Scopus
  19. V. Jakus, M. Hrnčiarová, J. Čársky, B. Krahulec, and N. Rietbrock, “Inhibition of nonenzymatic protein glycation and lipid peroxidation by drugs with antioxidant activity,” Life Sciences, vol. 65, no. 18-19, pp. 1991–1993, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. B. G. Mockett, D. Guévremont, M. Wutte, S. R. Hulme, J. M. Williams, and W. C. Abraham, “Calcium/calmodulin-dependent protein kinase II mediates group I metabotropic glutamate receptor-dependent protein synthesis and long-term depression in rat hippocampus,” Journal of Neuroscience, vol. 31, no. 20, pp. 7380–7391, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. A. J. Davidoff, M. M. Mason, M. B. Davidson et al., “Sucrose-induced cardiomyocyte dysfunction is both preventable and reversible with clinically relevant treatments,” American Journal of Physiology, vol. 286, no. 5, pp. E718–E724, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. T. A. Doser, S. Turdi, D. P. Thomas, P. N. Epstein, S. Y. Li, and J. Ren, “Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction,” Circulation, vol. 119, no. 14, pp. 1941–1949, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Y. Li, X. Yang, A. F. Ceylan-Isik, M. Du, N. Sreejayan, and J. Ren, “Cardiac contractile dysfunction in Lep/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco(endo)plasmic reticulum Ca2+-ATPase and myosin heavy chain isozyme switch,” Diabetologia, vol. 49, no. 6, pp. 1434–1446, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. A. J. Davidoff and J. Ren, “Low insulin and high glucose induce abnormal relaxation in cultured adult rat ventricular myocytes,” American Journal of Physiology, vol. 272, part 2, no. 1, pp. H159–H167, 1997. View at Google Scholar · View at Scopus
  25. J. Ren, L. J. Dominguez, J. R. Sowers, and A. J. Davidoff, “Metformin but not glyburide prevents high glucose-induced abnormalities in relaxation and intracellular Ca2+ transients in adult rat ventricular myocytes,” Diabetes, vol. 48, no. 10, pp. 2059–2065, 1999. View at Publisher · View at Google Scholar · View at Scopus
  26. L. E. Wold and J. Ren, “Mechanical measurement of contractile function of isolated ventricular myocytes,” Methods in Molecular Medicine, vol. 139, pp. 263–270, 2007. View at Google Scholar · View at Scopus
  27. J. Ren and L. E. Wold, “Measurement of cardiac mechanical function in isolated ventricular myocytes from rats and mice by computerized video-based imaging,” Biological Procedures Online, vol. 3, no. 1, pp. 43–53, 2001. View at Google Scholar · View at Scopus
  28. Y. Ti, G. L. Xie, Z. H. Wang et al., “TRB3 gene silencing alleviates diabetic cardiomyopathy in a type 2 diabetic rat model,” Diabetes, vol. 60, no. 11, pp. 2963–2974, 2011. View at Google Scholar
  29. U. Rajamani and M. F. Essop, “Hyperglycemia-mediated activation of the hexosamine biosynthetic pathway results in myocardial apoptosis,” American Journal of Physiology, vol. 299, no. 1, pp. C139–C147, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Yano, H. Tokumitsu, and T. R. Soderling, “Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway,” Nature, vol. 396, no. 6711, pp. 584–587, 1998. View at Publisher · View at Google Scholar · View at Scopus
  31. D. M. Bers, “Ca2+-calmodulin-dependent protein kinase II regulation of cardiac excitation-transcription coupling,” Heart Rhythm, vol. 8, no. 7, pp. 1101–1104, 2011. View at Publisher · View at Google Scholar · View at Scopus