Single Diabetic QTL Derived from OLETF Rat Is a Sufficient Agent for Severe Diabetic Phenotype in Combination with Leptin-Signaling Deficiency
Table 1
Comparison of metabolic parameters.
F344
F.ZF-lepr
F.ZF/O-lepr, Nidd1/of
F.ZF/O-lepr, Nidd2/of
F.ZF/O-lepr, Nidd1 and 2/of
OLETF
()
()
()
()
()
()
Glucose (mg/dL)
75.1 ± 2.6
94.5 ± 4.9
117.2 ± 6.1
117.4 ± 5.1
172.7 ± 11.2***
80.2 ± 2.6
Insulin (ng/mL)
2.21 ± 0.22
48.8 ± 5.2
78.4 ± 9.3*
70.9 ± 11.9
72.0 ± 10.5
1.63 ± 0.3*
TCHO (mg/dL)
64.8 ± 2.4
234.2 ± 26.2
439.3 ± 38.4**
227.2 ± 19.0
370.5 ± 55.9
97.9 ± 3.7
TG (mg/dL)
174.2 ± 15.0
1170 ± 165
1720 ± 145
777 ± 106
617 ± 122
122.7 ± 14.3**
NEFA (mEq/L)
0.87 ± 0.13
4.28 ± 0.50
6.33 ± 0.5*
3.45 ± 0.4
2.11 ± 0.4
0.75 ± 0.05*
Fat weight (g)
Mesenteric fat
7.1 ± 0.4
15.6 ± 0.8
14.5 ± 0.4
10.4 ± 0.5***
11.4 ± 1.7*
9.5 ± 0.5***
Retroperitoneal fat
7.6 ± 0.4
15.0 ± 0.8
14.5 ± 0.4
13.3 ± 0.6
13.2 ± 1.0
15.5 ± 1.2
Epididymal fat
9.0 ± 0.5
13.8 ± 0.6
12.5 ± 0.4
9.9 ± 0.3***
9.2 ± 1.0***
8.6 ± 0.5***
Adiposity index (%)a
Mesentric fat
2.23 ± 0.11
3.63 ± 0.16
3.52 ± 0.06
2.95 ± 0.18*
3.23 ± 0.34
1.96 ± 0.07***
Retroperitoneal fat
2.39 ± 0.09
3.47 ± 0.13
3.52 ± 0.07
3.72 ± 0.86
3.79 ± 0.11
3.20 ± 0.19
Epididymal fat
2.81 ± 0.11
3.23 ± 0.13
3.02 ± 0.06
2.79 ± 0.11
2.62 ± 0.14
1.79 ± 0.07*
Body weight (30 w) (g)
314.3 ± 5.6
417.5 ± 8.5
403.5 ± 9.3
349.8 ± 7.9***
343.8 ± 13.6**
481.0 ± 13.3*
TC: total cholesterol; TG: triglycerides; NEFA: nonesterified fatty acids. Sixteen-week-old fasted males were used for all measurements except glucose, insulin, and body weight, which were measured during OGTT analysis at 15 weeks of age. Data are shown as means ± SE.
aAdipocity index was determined using each fat pad and body weight (percentage of fat weight/body weight).
*
; **; *** versus F.ZF-lepr. F344 data are shown as reference, thus no statistical analysis was performed.