Research Article

Single Diabetic QTL Derived from OLETF Rat Is a Sufficient Agent for Severe Diabetic Phenotype in Combination with Leptin-Signaling Deficiency

Table 1

Comparison of metabolic parameters.

F344F.ZF-lepr F.ZF/O-lepr, Nidd1/of F.ZF/O-lepr, Nidd2/of F.ZF/O-lepr, Nidd1 and 2/of OLETF
( ) ( )( )( )( )( )

Glucose (mg/dL)75.1 ± 2.694.5 ± 4.9117.2 ± 6.1117.4 ± 5.1172.7 ± 11.2***80.2 ± 2.6
Insulin (ng/mL)2.21 ± 0.2248.8 ± 5.278.4 ± 9.3*70.9 ± 11.972.0 ± 10.51.63 ± 0.3*
TCHO (mg/dL)64.8 ± 2.4234.2 ± 26.2439.3 ± 38.4**227.2 ± 19.0370.5 ± 55.997.9 ± 3.7
TG (mg/dL)174.2 ± 15.01170 ± 1651720 ± 145 777 ± 106617 ± 122122.7 ± 14.3**
NEFA (mEq/L)0.87 ± 0.134.28 ± 0.506.33 ± 0.5*3.45 ± 0.42.11 ± 0.40.75 ± 0.05*
Fat weight (g)
 Mesenteric fat7.1 ± 0.415.6 ± 0.814.5 ± 0.410.4 ± 0.5***11.4 ± 1.7*9.5 ± 0.5***
 Retroperitoneal fat7.6 ± 0.415.0 ± 0.814.5 ± 0.413.3 ± 0.613.2 ± 1.015.5 ± 1.2
 Epididymal fat9.0 ± 0.513.8 ± 0.612.5 ± 0.49.9 ± 0.3***9.2 ± 1.0***8.6 ± 0.5***
Adiposity index (%)a
 Mesentric fat2.23 ± 0.113.63 ± 0.163.52 ± 0.062.95 ± 0.18*3.23 ± 0.341.96 ± 0.07***
 Retroperitoneal fat2.39 ± 0.093.47 ± 0.133.52 ± 0.073.72 ± 0.863.79 ± 0.113.20 ± 0.19
 Epididymal fat2.81 ± 0.113.23 ± 0.133.02 ± 0.062.79 ± 0.112.62 ± 0.141.79 ± 0.07*
Body weight (30 w) (g)314.3 ± 5.6417.5 ± 8.5403.5 ± 9.3349.8 ± 7.9***343.8 ± 13.6**481.0 ± 13.3*

TC: total cholesterol; TG: triglycerides; NEFA: nonesterified fatty acids.
Sixteen-week-old fasted males were used for all measurements except glucose, insulin, and body weight, which were measured during OGTT analysis at 15 weeks of age.
Data are shown as means ± SE.
aAdipocity index was determined using each fat pad and body weight (percentage of fat weight/body weight).
* ; ** ; *** versus F.ZF-lepr.
F344 data are shown as reference, thus no statistical analysis was performed.