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Experimental Diabetes Research
Volume 2012, Article ID 872176, 7 pages
Research Article

Association of FTO Polymorphisms with Early Age of Obesity in Obese Italian Subjects

1Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Policlinico Universitario, 09042 Cagliari, Italy
2Department of Clinical Sciences, University of Rome “Sapienza”, 00161 Rome, Italy
3Department of Molecular and Clinical Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research, University of Gothenburg, 431 45 Gothenburg, Sweden
4Department of Medical and Surgical Sciences, University of Magna Graecia, 88100 Catanzaro, Italy
5Department of Clinical and Medical Therapy, University of Rome “Sapienza”, 00185 Rome, Italy

Received 20 October 2011; Revised 10 December 2011; Accepted 10 December 2011

Academic Editor: Giuseppe Paolisso

Copyright © 2012 Federica Sentinelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Obesity is recognized as a major health problem worldwide. Genetic factors play a major role in obesity, and genomewide association studies have provided evidence that several common variants within the fat mass- and obesity-associated (FTO) gene are significantly associated with obesity. Very limited data is available on FTO in the Italian population. Aims of our study are to investigate: (1) the association of FTO gene SNPs rs9939609 and rs9930506 with body mass index (BMI) and obesity-related parameters in a large cohort (n=752) of Italian obese subjects; (2) the association between the two FTO SNPs and age of onset of obesity. Our results demonstrate a strong association between FTO SNPs rs9939609 (P<0.043) and rs9930506 (P<0.029) with BMI in the Italian population. FTO rs9930506 was significantly associated with higher BMI in a G allele dose-dependent manner (BMI+1.4 kg/m2 per G allele). We also observed that the association with BMI of the two FTO variants varied with age, with the carriers of the risk alleles developing an increase in body weight earlier in life. In conclusion, our study further demonstrates a role of the genetic variability in FTO on BMI in a large Italian population.