Journal of Diabetes Research / 2012 / Article / Tab 1

Research Article

Association of FTO Polymorphisms with Early Age of Obesity in Obese Italian Subjects

Table 1

Clinical characteristics of study subjects stratified for BMI.

NGroup A
Nonobese 198
Group B
Class I/II obese 330
P
A versus B
Group C
Class III obese 422
P
A versus C
P
B versus C

Women/men159/39222/108<0.001303/119<0.01NS
Age (yr)49 (45–55)48 (34–58)NS43 (35–51)<0.0010.005
Body mass index (kg/m2)a23.0 (21.3–24.7)35.7 (32.9–38.1)<0.00146.2 (42.8–51.1)<0.001<0.001
WAIST (cm)95.5 (91–100)112 (105–120)0.045132.5 (123–142)<0.001<0.001
SBP (mm/Hg)120 (115–135)130 (120–140)NS130 (120–140)NSNS
DBP (mm/Hg)80 (70–86)80 (75–90)NS85 (80–90)<0.001<0.001
Triglycerides (mg/dL)85.5 (65.6–120.3)127.3 (85.9–181)<0.001125 (88.6–163)<0.001NS
Total cholesterol (mg/dL)209 (187.2–234)203 (178–234)NS195 (170–218.3)<0.001<0.003
HDL cholesterol (mg/dL)59 (50–67)47.3 (40.3–56.6)<0.00145.8 (39.8–53)<0.001<0.033
LDL cholesterol (mg/dL)126 (108–147)124.2 (105–149)NS115 (95.1–139.6)<0.003<0.021
ALT (U/L)23 (13.1–34.5)27.5 (19.2–40)NS29.1 (20.7–45.6)NSNS
AST (U/L)20 (18–25)20 (16–27)NS20 (16–28)NSNS
Fasting blood glucose (mg/dL)92 (84–100)93 (82–118)NS95 (85–111)<0.001NS
Fasting blood insulin (μU/mL)9.9 (7–15.2)18.8 (13–30)<0.00129 (19.5–47.3)<0.001<0.001
HOMA-IR (U)2 (1.5–3.3)3.9 (2.6–6.7)<0.0016.2 (4.1–10.7)<0.001<0.001
ISI (U)4.6 (2.9–7.8)2.8 (1.8–4.4)<0.0011.9 (1.2–2.8)<0.001<0.001
Type 2 diabetes n (%)5 (2.5)101 (30.6)<0.001103 (24.4)<0.001<0.046

aBMI was calculated as body weight (kg)/height (m2). Values are medians and interquartile ranges. Abbreviations: SBP, systolic blood pressure; DBP, diastolic blood pressure; HDL, high density lipoprotein; LDL, low density lipoprotein; ALT, alanine transaminase; AST, aspartate transaminase; HOMA-IR, homeostatic model assessment of insulin resistance; ISI, insulin sensitivity index. Non-obese: BMI < 27 kg/m2; class I/II obese: BMI = 30-39.9 kg/m2; class III obese: BMI ≥ 40 kg/m2.

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