Association of FTO Polymorphisms with Early Age of Obesity in Obese Italian Subjects
Table 2
(a) Association study of FTO rs9939609 polymorphism with obesity. (b) Association study of FTO rs9930506 polymorphism with obesity.
(a)
Genotype n (%)
A-allele frequency (%)
P
n
TT
TA
AA
Stratified on BMI
Nonobese
198
68 (34.3)
90 (45.5)
40 (20.2)
43.0
<0.027
<0.038
Obese
752
195 (25.9)
357 (47.5)
200 (26.6)
50.3
Stratified on BMI
Nonobese
198
68 (34.3)
90 (45.5)
40 (20.2)
43.0
Class I/II obese
330
88 (26.7)
152 (46.1)
90 (27.2)
50.3
<0.066*
<0.075*
Class III obese
422
107 (25.4)
205 (48.6)
110 (26.0)
50.4
<0.038*
<0.057*
(b)
Genotype n (%)
G-allele frequency (%)
P
n
AA
AG
GG
Stratified on BMI
Nonobese
198
67 (33.8)
90 (45.5)
41 (20.7)
43.4
Obese
752
190 (25.3)
346 (46.0)
216 (28.7)
51.7
<0.013
<0.015
Stratified on BMI
Nonobese
198
67 (33.8)
90 (45.5)
41 (20.7)
43.4
Class I/II obese
330
86 (26.1)
149 (45.2)
95 (28.7)
51.4
<0.043*
<0.038*
Class III obese
422
104 (24.6)
197 (46.7)
121 (28.7)
52.0
<0.018*
<0.019*
Data are n (%). values were calculated using logistic regression analysis adjusted for age and sex. Nonobese: BMI < 27 kg/m2; class I/II obese: BMI = 30–39.9 kg/m2; class III obese: BMI ≥ 40 kg/m2. *versus nonobese
