Journal of Diabetes Research / 2012 / Article / Tab 2

Research Article

Association of FTO Polymorphisms with Early Age of Obesity in Obese Italian Subjects

Table 2

(a) Association study of FTO rs9939609 polymorphism with obesity. (b) Association study of FTO rs9930506 polymorphism with obesity.
(a)

Genotype n (%) A-allele frequency (%)P
nTTTAAA

Stratified on BMI
Nonobese19868 (34.3)90 (45.5)40 (20.2)43.0<0.027<0.038
Obese752195 (25.9)357 (47.5)200 (26.6)50.3
Stratified on BMI
Nonobese19868 (34.3)90 (45.5)40 (20.2)43.0
Class I/II obese33088 (26.7)152 (46.1)90 (27.2)50.3<0.066*<0.075*
Class III obese422107 (25.4)205 (48.6)110 (26.0)50.4<0.038*<0.057*

(b)

Genotype n (%) G-allele frequency (%)P
nAAAGGG

Stratified on BMI
Nonobese19867 (33.8)90 (45.5)41 (20.7)43.4
Obese752190 (25.3)346 (46.0)216 (28.7)51.7 <0.013<0.015
Stratified on BMI
Nonobese19867 (33.8)90 (45.5)41 (20.7)43.4
Class I/II obese33086 (26.1)149 (45.2)95 (28.7)51.4<0.043*<0.038*
Class III obese422104 (24.6)197 (46.7)121 (28.7)52.0<0.018*<0.019*

Data are n (%). values were calculated using logistic regression analysis adjusted for age and sex. Nonobese: BMI < 27 kg/m2; class I/II obese: BMI = 30–39.9 kg/m2; class III obese: BMI ≥ 40 kg/m2. *versus nonobese

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