Cholesterol-Lowering Probiotics as Potential Biotherapeutics for Metabolic Diseases

Table 2

Summary of major findings for probiotic mediated cholesterol reduction.

S. No.	Probiotic organism	Experimental system	Major findings	Reference
1	Unknown (fermented milk)	Maasai tribesmen in Africa	Low cholesterol	[45]
2	Unknown (Yogurt)	Human subjects	Reduced cholesterol	[46]
3	Lactobacillus acidophilus	Culture media	Cholesterol removal; Better survival in cholesterol media	[31]
4	Bifidobacterium	Culture media	Removal of cholesterol	[25]
5	L. acidophilus	Culture media	Cholesterol assimilation	[47]
6	Probiotic fermented milk	Rats	Cholesterol reducing efficacy	[48]
7	L. reuteri	Mice	Reduced blood cholesterol; Decreased triglycerides	[49]
8	Bifidobacterium milk	Rats, Human	Reduced cholesterol; Decreased triglyceride; Decreased LDL; Increased HDL	[50]
9	Yoghurt containing B. lactis or B. longum	Rats	Reduced cholesterol; Decreased triglyceride; Decreased LDL; Increased HDL	[51]
10	L. plantarum	Culture media	Cholesterol assimilation	[52]
11	L. bulgaricus and L. acidophilus	Human	Decreased cholesterol	Lin et al. [53]
12	Lactobacillus  sporogenes	Human	Decreased Cholesterol; Reduced LDL-cholesterol	[54].
13	L. acidophilus	Human	Decreased cholesterol	Gilliland [55]
14	E. faecium	Human	Decreased cholesterol levels; Decreased triglyceride; Decreased LDL; Increased HDL	[56]
15	Microencapsulated bile salt hydrolase- (BSH-) active Lactobacillus reuteri NCIMB 30242	Human	Reduced LDL-cholesterol; Decreased total; cholesterol; Decreased apoB-100; Decreased non-HDL-cholesterol	[57]