Regenerative Therapies for Diabetic Microangiopathy

Table 3

Role of gene transfer in the treatment of diabetic microangiopathy. Gene transfer promotes endothelial cell proliferation, migration, and blood vessel formation. VEGF: vascular endothelial growth factor; FGF: fibroblast growth factor; HGF: hepatocyte growth factor; HIF-1α: hypoxia inducible factor-1α.

	Study	Year	Identifier	Site	Status/recruited pts
VEGF	Vegf gene transfer for critical limb ischemia	2010	NCT00056290	Steward St. Elizabeth's Medical Center of Boston	Completed
	VEGF gene transfer for diabetic neuropathy	2010	NCT00056290	Steward St. Elizabeth's Medical Center of Boston	Completed
	Angiogenesis using VEGF-A165/bFGF plasmid delivered percutaneously in no-option CAD patients; a controlled trial (VIF-CAD)	2009	NCT00620217	Institute of Cardiology, Warsaw, Poland	Completed
FGF	Efficacy and safety study of NV1FGF in patients with severe peripheral artery occlusive disease (TALISMAN202)	2010	NCT00798005	Sanofi-Aventis	Completed
	Efficacy and safety of XRP0038/NV1FGF in critical limb ischemia patients with skin lesions (TAMARIS)	2010	NCT00566657	Sanofi-Aventis	This study is ongoing, but not recruiting participants
HGF	Study of hepatocyte growth factor (HGF) via plasmid vector to improve perfusion in critical limb ischemia patients with peripheral ischemic ulcers	2011	NCT00189540	AnGes	This study has been completed
HIF	Safety and efficacy study of Ad2/Hypoxia inducible factor-1α (HIF-1α)/VP16 gene transfer in patients with intermittent claudication (WALK)	2010	NCT00117650	Genzyme	This study has been completed