Journal of Diabetes Research / 2012 / Article / Tab 1

Research Article

Common Variants of Homocysteine Metabolism Pathway Genes and Risk of Type 2 Diabetes and Related Traits in Indians

Table 1

Anthropometric and clinical characteristics of the study populations.

CharacteristicsPhase 1Phase 2
Type 2 diabetes patientsControl SubjectsType 2 diabetes PatientsControl Subjects

N (Men/Women)1019 (592/427)1006 (606/400)1047 (619/428)1038 (516/522)
Age (years)53 (45–62)50 (44–60)55 (49–62)54 (45–64)
BMI (Kg/m2)
Men23.80 (22.00–26.00)23.10 (20.10–5.70)24.82 (22.68–27.76)24.68 (22.35–27.39)
Women26.70 (24.20–29.20)25.00 (21.10–8.50)27.39 (24.56–30.63)26.37 (23.13–29.33)
WHR
Men1.00 (0.97–1.03)0.97 (0.92–1.0)0.98 (0.95–1.03)0.97 (0.93–1.01)
Women1.00 (0.97–1.03)0.86 (0.82–0.92)0.93 (0.87–0.97)0.86 (0.82–0.90)
Systolic BP (mmHg)130 (130–140)120 (112–132)130 (122–140)130 (120–140)
Diastolic BP (mmHg)80 (78–90)80 (70–88)82 (80–90)80 (78–90)
HbA1c (%)7.80 (6.50–9.40)5.20 (4.90–5.60)8.20 (6.90–9.60)5.65 (5.33–5.89)
FPG (mmol/L)7.90 (6.40–10.30)4.90 (4.50–5.30)7.79 (6.21–10.27)4.87 (4.43–5.27)
2h PPG (mmol/L)5.57 (4.83–6.30)5.63 (4.88–6.22)
FPI (pmol/L)82.80 (42.0–166.80)32.40 (17.40–57.60)74.40 (26.00–96.00)43.80 (28.20–63.60)
HOMA-IR5.20 (2.30–9.60)1.20 (0.60–2.00)4.30 (2.30–9.30)1.60 (1.00–2.40)
HOMA-B60.25 (25.3–154.51)73.40 (40.70–138.60)61.66 (25.61–131.86)105.27 (65.13–167.32)
HOMA-S0.20 (0.10–0.46)0.86 (0.49–1.69)0.23 (0.11–0.44)0.64 (0.42–1.03)
C-peptide (nmol/L)0.89 (0.56–1.36)0.53 (0.36–0.73)1.05 (0.69–1.60)0.66 (0.50–0.86)
CRP (mg/L)2.20 (0.90–4.70)1.30 (0.60–3.00)1.86 (0.90–3.44)1.61 (0.90–3.04)
TC (mmol/L)4.20 (3.50–5.00)4.40 (3.7–5.10)4.64 (3.86–5.42)4.91 (4.22–5.52)
LDL-C (mmol/L)2.57 (1.99–3.36)2.79 (2.33–3.41)2.73 (2.10–3.42)3.01 (2.49–3.51)
HDL-C (mmol/L)1.03 (0.88–1.22)1.06 (0.88–1.28)1.11 (0.94–1.34)1.24 (1.06–1.46)
TG (mmol/L)1.60 (1.10–2.20)1.30 (1.00–1.80)1.43 (0.98–2.13)1.22 (0.86–1.64)

Values provided are median (interquartile range).
N: number of individuals, BMI: body mass index, WHR: waist to hip ratio, BP: blood pressure, HbA1c: glycosylated haemoglobin 1c, FPG: fasting plasma glucose, 2h PPG: 2h postload plasma glucose, FPI: fasting plasma insulin, HOMA-IR: homeostasis model assessments of insulin resistance, HOMA-B: homeostasis model assessments for β-cell function, HOMA-S: homeostasis model assessments for insulin sensitivity, CRP: C-reactive protein, TC: total cholesterol, LDL-C: low-density lipoprotein cholesterol, HDL-C: high-density lipoprotein-cholesterol, TG: triglyceride.

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