Journal of Diabetes Research / 2012 / Article / Tab 2

Research Article

Common Variants of Homocysteine Metabolism Pathway Genes and Risk of Type 2 Diabetes and Related Traits in Indians

Table 2

Variants showing association (uncorrected P-value) with type 2 diabetes and obesity.

TraitGeneSNPAllele
(major/minor)
MAF
(affected/unaffected)
OR (95% CI)P

Type 2 diabetes (total study population: 1019 cases versus 1006 controls)MTHFRrs1801133C/T0.18/0.210.78 (0.67–0.92)0.003

Type 2 diabetes (Normal weight subjects: 290 cases versus 436 controls)MTHFRrs1801133C/T0.18/0.210.62 (0.46–0.85)0.002
MTHFRrs9651118C/T0.26/0.251.31 (1.01–1.68)0.04
CHDHrs4563403G/A0.10/0.110.66 (0.45–0.95)0.02
CBSrs706208T/C0.41/0.391.30 (1.03–1.63)0.03
MTHFD1Lrs1555179C/T0.26/0.231.36 (1.04–1.78)0.03

Type 2 diabetes (Obese/over-weight subjects: 691cases versus 562 controls)MTHFD1rs1076991A/G0.40/0.440.81 (0.69–0.95)0.01
TCN2rs1801198G/C0.42/0.440.85 (0.72–0.99)0.04

Obesity (562 Obese/over-weight versus 436 normal weights)CHDHrs4563403G/A0.09/0.130.69 (0.52–0.92)0.01
TCN2rs1801198G/C0.46/0.411.24 (1.04–1.48)0.02
MTRrs16834521T/C0.31/0.350.82 (0.68–0.99)0.04

Analyses adjusted for sex, age, and BMI. Analysis performed only in control subjects and adjusted for sex and age, MAF: minor allele frequency, OR: odds ratio, CI: confidence interval.

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