Common Variants of Homocysteine Metabolism Pathway Genes and Risk of Type 2 Diabetes and Related Traits in Indians
Table 3
Association of rs1801133 with all traits in initial phase, replication phase, and meta-analysis.
Trait
Initial phase
Replication phase
Meta-analysis
OR/β(95% CI)
P
OR/β (95% CI)
P
Q
I
Type2 diabetes (all) †
0.78 (0.67–0.92)
0.003
1.01 (0.87–1.19)
0.86
0.05
0.38
0.90
0.89
0.024
80.44
Type2 diabetes (NW) †
0.62 (0.46–0.85)
0.002
1.11(0.80–1.54)
0.53
0.07
0.52
0.81
0.83
0.012
84.30
Type2 diabetes (OW/OB) †
0.86 (0.71–1.04)
0.13
0.98 (0.82–1.17)
0.85
0.25
0.25
0.93
0.93
0.32
0.25
Obesity (NW versus OW/OB) ‡
1.07 (0.86–1.33)
0.56
1.11 (0.86–1.43)
0.42
0.33
0.33
1.09
1.09
0.82
0
BMI‡
0.32 ((−0.19)–(−0.84))
0.22
0.25 (−0.26–0.76)
0.34
0.12
0.12
0.29
0.29
0.84
0
Weight‡
1.41 (0.02–2.80)
0.05
0.43 (−0.95–1.81)
0.54
0.07
0.07
0.92
0.92
0.33
0
WC‡
0.47 (−0.76–1.70)
0.45
0.28 (−1.12–1.68)
0.70
0.41
0.41
0.39
0.39
0.84
0
WHR‡
−0.003 (−0.01–0.005)
0.46
−0.005 (−0.01–0.003)
0.24
0.18
0.18
−0.004
−0.004
0.73
0
FPG†
0.55 (−0.66–1.77)
0.37
-0.83 (−2.14–0.47)
0.21
0.84
0.86
−0.09
−0.12
0.13
56.98
2h PPG†
−5.06 ((−9.72)–(−0.40))
0.03
−1.13 (−4.84–2.58)
0.55
0.07
0.15
−2.65
−2.83
0.20
40.15
HbA1c†
0.02 (−0.03–0.07)
0.41
−0.03 (−0.07–0.01)
0.15
0.58
0.79
−0.009
−0.007
0.12
59.73
FPI†
0.43 (−0.44–1.30)
0.33
−0.77 ((−1.42)–(−0.11))
0.02
0.21
0.73
−0.33
−0.20
0.03
78.49
HOMA-IR†
0.11 (−0.09–0.31)
0.30
−0.20 ((−0.36)–(−0.04))
0.01
0.21
0.73
−0.08
−0.05
0.02
81.77
HOMA-B†
70.25 (−34.99–175.50)
0.19
−652.8 ((−1165)–(−140.1))
0.01
0.44
0.49
41.02
−245.94
0.0068
86.36
HOMA-S†
−0.09 (−0.26–0.07)
0.27
0.62 (0.13–1.11)
0.01
0.82
0.53
−0.02
0.23
0.0067
86.41
C-peptide†
0.01 (−0.10–0.12)
0.86
−0.07 (−0.17–0.04)
0.22
0.44
0.44
−0.03
−0.03
0.32
0
CRP†
−0.16 (−0.38–0.05)
0.14
−0.12 (−0.34–0.1)
0.28
0.07
0.07
−0.14
−0.14
0.79
0
HDL-C†
2.14 (0.68–3.59)
0.004
−0.05 (−1.31–1.21)
0.94
0.07
0.36
0.89
1.01
0.03
79.83
LDL-C†
3.25 (−0.32–6.81)
0.07
2.61 (−1.03–6.26)
0.16
0.02
0.02
2.94
2.94
0.81
0
TC†
5.61 (1.28–9.94)
0.01
2.02 (−2.43–6.47)
0.37
0.01
0.03
3.86
3.85
0.26
22.03
TG†
7.08 (−0.88–15.05)
0.08
−3.73 (−10.26–2.81)
0.26
0.81
0.79
0.62
1.43
0.04
76.37
Systolic BP†
1.53 (−0.41–3.48)
0.12
−0.77 (−2.58–1.03)
0.40
0.66
0.76
0.29
0.35
0.09
65.50
Diastolic BP†
0.77 (−0.30–1.85)
0.16
−0.74 (−1.82–0.35)
0.18
0.95
0.98
0.02
0.02
0.05
73.47
Creatinine†
0.02 (−0.004–0.04)
0.11
−0.01 (−0.05–0.02)
0.50
0.33
0.68
0.01
0.01
0.16
50.00
Urea†
0.28 (−0.63–1.20)
0.54
−0.12 (−1.14–0.9)
0.82
0.76
0.76
0.10
0.10
0.57
0
Uric acid†
0.37 (−0.02–0.76)
0.06
0.05 (−0.1–0.19)
0.55
0.22
0.31
0.09
0.15
0.13
56.68
†Analyses adjusted for sex, age, and BMI. ‡Analysis performed only in control subjects and adjusted for sex and age. OR: odds ratio, CI: confidence interval, : value for fixed effect, : value for random effect ORf: odds ratio for fixed effect, β f: beta value for fixed effect, ORr: odds ratio for random effect, : beta value for random effect, Q: value for Cochrane's Q statistic, and I: heterogeneity index (0–100).
