Journal of Diabetes Research / 2012 / Article / Tab 3

Research Article

Common Variants of Homocysteine Metabolism Pathway Genes and Risk of Type 2 Diabetes and Related Traits in Indians

Table 3

Association of rs1801133 with all traits in initial phase, replication phase, and meta-analysis.

Trait Initial phase Replication phaseMeta-analysis
OR/β(95% CI)POR/β (95% CI)P QI

Type2 diabetes (all)0.78 (0.67–0.92)0.0031.01 (0.87–1.19)0.860.050.380.900.890.02480.44
Type2 diabetes (NW)0.62 (0.46–0.85)0.0021.11(0.80–1.54)0.530.070.520.810.830.01284.30
Type2 diabetes (OW/OB)0.86 (0.71–1.04)0.130.98 (0.82–1.17)0.850.250.250.930.930.320.25
Obesity (NW versus OW/OB)1.07 (0.86–1.33)0.561.11 (0.86–1.43)0.420.330.331.091.090.820
BMI0.32 ((−0.19)–(−0.84))0.220.25 (−0.26–0.76)0.340.120.120.290.290.840
Weight1.41 (0.02–2.80)0.050.43 (−0.95–1.81)0.540.070.070.920.920.330
WC0.47 (−0.76–1.70)0.450.28 (−1.12–1.68)0.700.410.410.390.390.840
WHR−0.003 (−0.01–0.005)0.46−0.005 (−0.01–0.003)0.240.180.18−0.004−0.0040.730
FPG0.55 (−0.66–1.77)0.37-0.83 (−2.14–0.47)0.210.840.86−0.09−0.120.1356.98
2h PPG−5.06 ((−9.72)–(−0.40))0.03−1.13 (−4.84–2.58)0.550.070.15−2.65−2.830.2040.15
HbA1c0.02 (−0.03–0.07)0.41−0.03 (−0.07–0.01)0.150.580.79−0.009−0.0070.1259.73
FPI0.43 (−0.44–1.30)0.33−0.77 ((−1.42)–(−0.11))0.020.210.73−0.33−0.200.0378.49
HOMA-IR0.11 (−0.09–0.31)0.30−0.20 ((−0.36)–(−0.04))0.010.210.73−0.08−0.050.0281.77
HOMA-B70.25 (−34.99–175.50)0.19−652.8 ((−1165)–(−140.1))0.010.440.4941.02−245.940.006886.36
HOMA-S−0.09 (−0.26–0.07)0.270.62 (0.13–1.11)0.010.820.53−0.020.230.006786.41
C-peptide0.01 (−0.10–0.12)0.86−0.07 (−0.17–0.04)0.220.440.44−0.03−0.030.320
CRP−0.16 (−0.38–0.05)0.14−0.12 (−0.34–0.1)0.280.070.07−0.14−0.140.790
HDL-C2.14 (0.68–3.59)0.004−0.05 (−1.31–1.21)0.940.070.360.891.010.0379.83
LDL-C3.25 (−0.32–6.81)0.072.61 (−1.03–6.26)0.160.020.022.942.940.810
TC5.61 (1.28–9.94)0.012.02 (−2.43–6.47)0.370.010.033.863.850.2622.03
TG7.08 (−0.88–15.05)0.08−3.73 (−10.26–2.81)0.260.810.790.621.430.0476.37
Systolic BP1.53 (−0.41–3.48)0.12−0.77 (−2.58–1.03)0.400.660.760.290.350.0965.50
Diastolic BP0.77 (−0.30–1.85)0.16−0.74 (−1.82–0.35)0.180.950.980.020.020.0573.47
Creatinine0.02 (−0.004–0.04)0.11−0.01 (−0.05–0.02)0.500.330.680.010.010.1650.00
Urea0.28 (−0.63–1.20)0.54−0.12 (−1.14–0.9)0.820.760.760.100.100.570
Uric acid0.37 (−0.02–0.76)0.060.05 (−0.1–0.19)0.550.220.310.090.150.1356.68

Analyses adjusted for sex, age, and BMI.
Analysis performed only in control subjects and adjusted for sex and age.
OR: odds ratio, CI: confidence interval, : value for fixed effect, : value for random effect ORf: odds ratio for fixed effect, β f: beta value for fixed effect, ORr: odds ratio for random effect, : beta value for random effect, Q: value for Cochrane's Q statistic, and I: heterogeneity index (0–100).

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