A Novel Rat Model of Type 2 Diabetes: The Zucker Fatty Diabetes Mellitus ZFDM Rat

Table 1

Characteristics of the ZDF and ZFDM strains.

	ZDF	ZFDM
Origin	ZF colony at Eli Lilly Research Laboratories (Indianapolis, IN)	ZF colony at Tokyo Medical University (Tokyo, Japan)
Genetic control	Inbred	Outbred
Obesity*	Early onset (6–10 wk)	Early onset (6–12 wk)
Diabetes*	Young-age onset (8–12 wk)	Young- to middle-age onset (10–20 wk)
Special diet	Purina 5008	Not needed
Breeding	♀ 𝑓𝑎/+ ×  ♂ 𝑓𝑎/+	♀  𝑓𝑎/+ ×  ♂ 𝑓𝑎/𝑓𝑎

*Characteristics of fa/fa male rats in the ZDF and ZFDM strains.