Table 1: Characteristics of the ZDF and ZFDM strains.

ZDFZFDM

OriginZF colony at Eli Lilly Research Laboratories (Indianapolis, IN)ZF colony at Tokyo Medical University (Tokyo, Japan)
Genetic controlInbredOutbred
Obesity*Early onset (6–10 wk)Early onset (6–12 wk)
Diabetes*Young-age onset (8–12 wk)Young- to middle-age onset (10–20 wk)
Special dietPurina 5008Not needed
Breeding + ×  ♂ +♀   + ×  ♂

*Characteristics of fa/fa male rats in the ZDF and ZFDM strains.