The Role of Adrenomedullin in the Renal NADPH Oxidase and (Pro)renin in Diabetic Mice

Figure 2

PAS staining of the glomerulus (a). The glomerular matrix expansion score (b) and its correlation with the glomerular malondialdehyde (MDA) staining score (c). The mesangial matrix was segmentally increased in both the STZ-induced diabetic wild mice (Wild-DM) and the diabetic adrenomedullin gene knockout (AMKO) mice (AMKO-DM) compared with that observed in the control mice (Wild-C and AMKO-C). (a) The bar indicates 50 𝜇m. (b) The AMKO-DM mice exhibited a significant increase in the mesangial matrix expansion score compared with the wild-DM mice. Four mice in each group. ^∗𝑃<0.005, ^∗∗𝑃<0.0001 versus Wild-C, ⁺𝑃<0.01, ⁺⁺𝑃<0.0001 versus AMKO-C, and ^#𝑃<0.01 versus Wild-DM. (c) The white circles indicate wild-control mice, the black circles, diabetic wild mice, the white triangles indicate adrenomedullin gene knockout (AMKO)-control mice, and the black triangles indicate diabetic AMKO mice. 𝑅=0.96, 𝑃<0.05.

(a)

(b)

(c)