The Hypocholesterolemic Effect of Germinated Brown Rice Involves the Upregulation of the Apolipoprotein A1 and Low-Density Lipoprotein Receptor Genes
Changes in the expression levels of (a) the low-density lipoprotein receptor (LDL-R) gene and (b) the apolipoprotein A1 (APO A1) genes in HEPG2 cells following 24 h of treatment. The figure shows the effect of 50 ppm of acylated steryl glycoside (ASG), -amino butyric acid (GABA), oryzanol, and phenolic extracts on the expression levels of LDL-R and APO A1 genes in HEPG2 cells following 24 h of treatment compared with the effects of insulin (100 nM) and no treatment (). The data represent the means of each group, and the error bars represent SDs. *Bioactive group significantly higher than the control group. **Bioactive group significantly higher than the insulin group ().