Review Article
Comparison of Two New Mouse Models of Polygenic Type 2 Diabetes at the Jackson Laboratory, NONcNZO10Lt/J and TALLYHO/JngJ
Table 2
Summary comparison of the 3 models.
| ā | BKS-db/db | NONcNZO10/LtJ | TALLYHO/JngJ |
| Obesity | Monogenic, morbid | Polygenic, moderate | Polygenic, moderate | Diabetes | Juvenile onset | Maturity onset | Maturity onset | Leptin resistance | Central, total | Peripheral, moderate | Peripheral, moderate | Insulin resistance | Severe | Moderate | Moderate | Sex bias | None | Males | Males | Littermate controls | Yes | No | No | Fertile | No | Yes | Yes |
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