Benidipine Protects Kidney through Inhibiting ROCK1 Activity and Reducing the Epithelium-Mesenchymal Transdifferentiation in Type 1 Diabetic Rats
Immunohistochemistry expression (envision ×400). (a), (e), and (i) are for N group; (b), (f), and (j) are for D group; (c), (g), and (k) are for F group; and (d), (h), and (l) are for B group. (a), (b), (c), and (d) are the expression of ROCK1; (e), (f), (g), and (h) are the expression of -SMA; (i), (j), (k), and (l) are the expression of E-cadherin. The brown color in plasma, membrane represented positive expression. (a) showed little expression of ROCK1 in renal tubular epithelium cells; (b) showed widely expressed ROCK1 in renal tubular epithelium cells; (c) and (d) showed the range and degree of staining slighter than those of B group. (e) showed that -SMA is only expressed in the smooth muscle cells of renal small artery; (f) showed that -SMA is expressed in renal tubular epithelium cells; (g) and (h) showed no expression in renal epithelium cells; (i) showed the expression of E-cadherin in renal tubular epithelium membrane; (j) showed no expression; (k) and (l) showed partial expression of E-cadherin on the surface of the cell membrane.
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