Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats

Figure 11

The sorbitol levels in the sciatic nerves at 15 weeks. The sorbitol level in the sciatic nerves in the untreated SDT rats is significantly higher that of the SD rats. ^∗∗𝑃<0.01, Student’s 𝑡-test. The sorbitol levels in the sciatic nerves treated with ranirestat (1.0 and 10 mg/kg/day) are significantly lower than those in the untreated SDT rats. ^‡𝑃<0.01, Dunnett type joint-ranking test. The sorbitol level in the sciatic nerves treated with epalrestat is also significantly lower than in the untreated SDT rats. ^‡𝑃<0.01, Student’s 𝑡-test. NDM: non-diabetes mellitus; DM: diabetes mellitus; rani: ranirestat; epal: epalrestat.