Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats

Figure 13

The fructose levels in the sciatic nerves at 15 weeks. The fructose level in the sciatic nerves of the untreated SDT rats is significantly higher that of the SD rats. ^∗∗𝑃<0.01, Student’s 𝑡-test. The fructose levels in the sciatic nerves treated with ranirestat (1.0 and 10 mg/kg/day) are significantly lower than in the untreated SDT rats. ^‡𝑃<0.01, Dunnett type joint-ranking test. The fructose levels in the sciatic nerves treated with epalrestat are also significantly lower than in the untreated SDT rats. ^‡𝑃<0.01, Student’s 𝑡-test. NDM: non-diabetes mellitus; DM: diabetes mellitus; rani: ranirestat; epal: epalrestat.