Journal of Diabetes Research / 2013 / Article / Fig 8

Research Article

Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats

Figure 8

The sorbitol levels in the lenses at 40 weeks. Although there seems to be a dose-dependent decrease in the sorbitol levels in the lenses with administration of ranirestat, the sorbitol levels in the untreated lenses and in those treated with epalrestat are very low. NDM: non-diabetes mellitus; DM: diabetes mellitus; rani: ranirestat; epa: epalrestat.