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Journal of Diabetes Research
Volume 2013, Article ID 245271, 8 pages
Research Article

Ethyl Pyruvate Inhibits Retinal Pathogenic Neovascularization by Downregulating HMGB1 Expression

Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine (KIOM), 1672 Yuseongdaero, Yuseong-gu, Daejeon 305-811, Republic of Korea

Received 26 July 2013; Revised 18 October 2013; Accepted 8 November 2013

Academic Editor: Ronald G. Tilton

Copyright © 2013 Yun Mi Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

We performed animal study using a selective inhibitor of HMGB1, glycyrrhizin (GL). GL is a triterpenoid saponin glycoside of glycyrrhizic acid. GL does not interfere with HMGB1 release, but directly inhibit its extracellular cytokine activities [46]. GL treatment also significantly reduced the area of neovascularization in retinas compared with OIR.

  1. Supplementary Materials