Association of the Receptor for Advanced Glycation End Products Gene Polymorphisms and Circulating RAGE Levels with Diabetic Retinopathy in the Chinese Population
Table 2
Genotype and allele frequencies of RAGE gene polymorphisms in diabetic patients with and without retinopathy.
Polymorphism
Genotype
Genotype distribution
Alleles
Allele frequency
Cases
Control
OR (95% CI)
P
Cases
Control
P
2184A/G rs3134940 ()
A/A
235
448
1.00
0.35
A
0.82
0.84
0.28
A/G
108
167
0.81 (0.61–1.08)
G
0.18
0.16
G/G
8
16
1.05 (0.44–2.49)
1704G/T rs184003 ()
G/G
266
490
1.00
0.40
0.85
0.85
0.77
G/T
98
156
0.86 (0.64–1.16)
0.15
0.15
T/T
8
21
1.42 (0.62–3.26)
rs1035798 ()
C/C
274
467
1.00
0.08
C
0.85
0.84
0.57
C/T
83
183
1.29 (0.96–1.74)
T
0.15
0.16
T/T
15
16
0.63 (0.30–1.29)
G82S rs2070600 ()
G/G
195
396
1.00
0.0035*
G
0.70
0.76
0.0015*
G/S
131
227
1.17 (0.89–1.54)
S
0.30
0.24
S/S
46
44
2.12 (1.36–3.32)
−429T/C rs1800625 ()
T/T
280
502
1.00
0.42
T
0.86
0.87
0.63
C/T
80
150
1.05 (0.77–1.42)
C
0.14
0.13
C/C
12
13
0.60 (0.27–1.34)
The Chi-square test was used to compare the genotype and allele frequencies between DR and NDR groups.
*
P < 0.05 was considered statistically significant.
