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Journal of Diabetes Research
Volume 2013, Article ID 329596, 5 pages
http://dx.doi.org/10.1155/2013/329596
Review Article

Bone Marrow Stem Cell as a Potential Treatment for Diabetes

Department of Stem Cell Disorders, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan

Received 11 December 2012; Accepted 8 March 2013

Academic Editor: Gordana Kocic

Copyright © 2013 Ming Li and Susumu Ikehara. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diabetes mellitus (DM) is a group of metabolic diseases in which a person has high blood glucose levels resulting from defects in insulin secretion and insulin action. The chronic hyperglycemia damages the eyes, kidneys, nerves, heart, and blood vessels. Curative therapies mainly include diet, insulin, and oral hypoglycemic agents. However, these therapies fail to maintain blood glucose levels in the normal range all the time. Although pancreas or islet-cell transplantation achieves better glucose control, a major obstacle is the shortage of donor organs. Recently, research has focused on stem cells which can be classified into embryonic stem cells (ESCs) and tissue stem cells (TSCs) to generate functional β cells. TSCs include the bone-marrow-, liver-, and pancreas-derived stem cells. In this review, we focus on treatment using bone marrow stem cells for type 1 and 2 DM.