IL-10 Induction from Implants Delivering Pancreatic Islets and Hyaluronan
Figure 4
BI designed for evaluation of immune modulation by HA in vivo. (a) Cut-away diagram of the BI. A disk-shaped PVA sponge (Sp) scaffold provides mechanical support. Alginate spheres (AS-blue) occupy the six peripheral holes (PH) of the sponge. A central hole in the sponge contains islets (yellow) suspended in a type 1 collagen hydrogel (not shown). The collagen hydrogel also infuses the sponge. For clarity, the pores of the sponge are not depicted. (b) A PVA sponge scaffold (stained pink from culture medium) is oriented to show the empty central hole (asterisk) and the six peripheral holes, which each contain an alginate sphere (e.g., arrow). The scaffold is 10 mm in diameter × 2 mm thick.
