Research Article

Angiotensin-Converting Enzyme 2 Deficiency Aggravates Glucose Intolerance via Impairment of Islet Microvascular Density in Mice with High-Fat Diet

Table 2

Data of immunohistochemistry (mean ± SD).

    WTWHKOKH

Insulin relative concentration−4.00 ± 0.05−4.63 ± 0.06*−4.10 ± 0.04−5.07 ± 0.06*#△
Insulin-positive cell density2.35 ± 0.022.30 ± 0.012.32 ± 0.022.28 ± 0.01
Microvascular density13.52 ± 0.48 17.09 ± 0.52*11.87 ± 0.457.89 ± 0.46*#△
Relative content of VEGF−4.67 ± 0.11−3.99 ± 0.05*−4.91 ± 0.04−5.11 ± 0.04*#△

WT: wild type mice; WH: wild type mice with high-fat diet; KO: ACE2 knockout mice; KH: ACE2 knockout mice with high-fat diet. VEGF: vascular endothelial growth factor, versus WT * , versus KO # , and versus WH .