Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2013, Article ID 432695, 6 pages
http://dx.doi.org/10.1155/2013/432695
Research Article

Fortified Extract of Red Berry, Ginkgo biloba, and White Willow Bark in Experimental Early Diabetic Retinopathy

Department of Clinical and Molecular Biomedicine, Section of Pharmacology and Biochemistry, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy

Received 16 March 2013; Accepted 7 May 2013

Academic Editor: Ghulam Mohammad

Copyright © 2013 Claudio Bucolo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. A. Kowluru and P. S. Chan, “Oxidative stress and diabetic retinopathy,” Experimental Diabesity Research, vol. 2007, Article ID 43603, 12 pages, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. L. P. Aiello, J. M. Northrup, B. A. Keyt, H. Takagi, and M. A. Iwamoto, “Hypoxic regulation of vascular endothelial growth factor in retinal cells,” Archives of Ophthalmology, vol. 113, no. 12, pp. 1538–1544, 1995. View at Google Scholar · View at Scopus
  3. G. A. Limb, L. Webster, H. Soomro, S. Janikoun, and J. Shilling, “Platelet expression of tumour necrosis factor-alpha (TNF-α), TNF receptors and intercellular adhesion molecule-1 (ICAM-1) in patients with proliferative diabetic retinopathy,” Clinical and Experimental Immunology, vol. 118, no. 2, pp. 213–218, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Tang and T. S. Kern, “Inflammation in diabetic retinopathy,” Progress in Retinal and Eye Research, vol. 30, no. 5, pp. 343–358, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Wu, G. Xu, Y. Liao et al., “Supplementation with antioxidants attenuates transient worsening of retinopathy in diabetes caused by acute intensive insulin therapy,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 250, no. 10, pp. 1453–1458, 2012. View at Publisher · View at Google Scholar
  6. C. Bucolo, G. M. Leggio, F. Drago, and S. Salomone, “Eriodictyol prevents early retinal and plasma abnormalities in streptozotocin-induced diabetic rats,” Biochemical Pharmacology, vol. 84, no. 1, pp. 88–92, 2012. View at Publisher · View at Google Scholar
  7. S. G. Lee, C. G. Lee, I. H. Yun, D. Y. Hur, J. W. Yang, and H. W. Kim, “Effect of lipoic acid on expression of angiogenic factors in diabetic rat retina,” Clinical & Experimental Ophthalmology, vol. 40, no. 1, pp. e47–e57, 2012. View at Publisher · View at Google Scholar
  8. F. Pfister, E. Riedl, Q. Wang et al., “Oral carnosine supplementation prevents vascular damage in experimental diabetic retinopathy,” Cellular Physiology and Biochemistry, vol. 28, no. 1, pp. 125–136, 2011. View at Publisher · View at Google Scholar
  9. L. Packer, E. H. Witt, and H. J. Tritschler, “Alpha-lipoic acid as a biological antioxidant,” Free Radical Biology and Medicine, vol. 19, no. 2, pp. 227–250, 1995. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Kojima, L. Sun, I. Hata, Y. Sakamoto, H. Sasaki, and K. Sasaki, “Efficacy of α-lipoic acid against diabetic cataract in rat,” Japanese Journal of Ophthalmology, vol. 51, no. 1, pp. 10–13, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. Z. Kyselova, M. Stefek, and V. Bauer, “Pharmacological prevention of diabetic cataract,” Journal of Diabetes and Its Complications, vol. 18, no. 2, pp. 129–140, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. R. A. Kowluru, J. Tang, and T. S. Kern, “Abnormalities of retinal metabolism in diabetes and experimental galactosemia: VII. Effect of long-term administration of antioxidants on the development of retinopathy,” Diabetes, vol. 50, no. 8, pp. 1938–1942, 2001. View at Google Scholar · View at Scopus
  13. R. A. Kowluru and S. Odenbach, “Effect of long-term administration of α-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats,” Diabetes, vol. 53, no. 12, pp. 3233–3238, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. R. A. Kowluru and M. Kanwar, “Effects of curcumin on retinal oxidative stress and inflammation in diabetes,” Nutrition and Metabolism, vol. 4, article no. 8, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. R. A. Kowluru, M. Kanwar, and A. Kennedy, “Metabolic memory phenomenon and accumulation of peroxynitrite in retinal capillaries,” Experimental Diabesity Research, vol. 2007, Article ID 21976, 7 pages, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Pacher, I. G. Obrosova, J. G. Mabley, and C. Szabó, “Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies,” Current Medicinal Chemistry, vol. 12, no. 3, pp. 267–275, 2005. View at Google Scholar · View at Scopus
  17. S. H. Jung, K. D. Kang, D. Ji et al., “The flavonoid baicalin counteracts ischemic and oxidative insults to retinal cells and lipid peroxidation to brain membranes,” Neurochemistry International, vol. 53, no. 6-8, pp. 325–337, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Rahman, “Studies on free radicals, antioxidants, and co-factors,” Clinical Interventions in Aging, vol. 2, no. 2, pp. 219–236, 2007. View at Google Scholar · View at Scopus
  19. G. Marrazzo, P. Bosco, F. La Delia et al., “Neuroprotective effect of silibinin in diabetic mice,” Neuroscience Letters, vol. 504, no. 3, pp. 252–256, 2011. View at Publisher · View at Google Scholar
  20. C. Nizard, E. Noblesse, C. Boisdé et al., “Heat shock protein 47 expression in aged normal human fibroblasts: modulation by Salix alba extract,” Annals of the New York Academy of Sciences, vol. 1019, pp. 223–227, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. J. J. Gagnier, M. W. van Tulder, B. Berman, and C. Bombardier, “Herbal medicine for low back pain: a Cochrane review,” Spine, vol. 32, no. 1, pp. 82–92, 1976. View at Google Scholar
  22. I. Ilieva, K. Ohgami, K. Shiratori et al., “The effects of Ginkgo biloba extract on lipopolysaccharide-induced inflammation in vitro and in vivo,” Experimental Eye Research, vol. 79, no. 2, pp. 181–187, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Yoshikawa, Y. Naito, and M. Kondo, “Ginkgo biloba leaf extract: review of biological actions and clinical applications,” Antioxidants and Redox Signaling, vol. 1, no. 4, pp. 469–480, 1999. View at Google Scholar · View at Scopus
  24. C. Bucolo, K. W. Ward, E. Mazzon, S. Cuzzocrea, and F. Drago, “Protective effects of a coumarin derivative in diabetic rats,” Investigative Ophthalmology and Visual Science, vol. 50, no. 8, pp. 3846–3852, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Faro, T. Avitabile, and G. Malaguarnera, “Effect of an antioxidant blend in diabetic macular edema,” Investigative Ophthalmology & Visual Science, vol. 54, p. 1968, 2013, E-Abstract. View at Google Scholar
  26. Y. Ozawa, T. Kurihara, M. Sasaki et al., “Neural degeneration in the retina of the streptozotocin-induced type 1 diabetes model,” Experimental Diabetes Research, vol. 2011, Article ID 108328, 7 pages, 2011. View at Publisher · View at Google Scholar
  27. A. Amore and R. Coppo, “Role of apoptosis in pathogenesis and progression of renal diseases,” Nephron, vol. 86, no. 2, pp. 99–104, 2000. View at Google Scholar · View at Scopus
  28. A. B. El-Remessy, M. Al-Shabrawey, Y. Khalifa, N. T. Tsai, R. B. Caldwell, and G. I. Liou, “Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes,” American Journal of Pathology, vol. 168, no. 1, pp. 235–244, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. A. M. Joussen, V. Poulaki, N. Mitsiades et al., “Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression,” The FASEB Journal, vol. 16, no. 3, pp. 438–440, 2002. View at Google Scholar · View at Scopus
  30. S. A. Vinores, W. H. Xiao, J. Shen, and P. A. Campochiaro, “TNF-α is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage,” Journal of Neuroimmunology, vol. 182, no. 1-2, pp. 73–79, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. A. M. Joussen, S. Doehmen, M. L. Le et al., “TNF-α mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterations,” Molecular Vision, vol. 15, pp. 1418–1428, 2009. View at Google Scholar · View at Scopus
  32. M. Amadio, C. Bucolo, G. M. Leggio, F. Drago, S. Govoni, and A. Pascale, “The PKCβ/HuR/VEGF pathway in diabetic retinopathy,” Biochemical Pharmacology, vol. 80, no. 8, pp. 1230–1237, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. T. Awata, K. Inoue, S. Kurihara et al., “A common polymorphism in the 5′-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes,” Diabetes, vol. 51, no. 5, pp. 1635–1639, 2002. View at Google Scholar · View at Scopus
  34. S. Rangasamy, P. G. McGuire, and A. Das, “Diabetic retinopathy and inflammation: novel therapeutic targets,” Middle East African Journal of Ophthalmology, vol. 19, pp. 52–59, 2012. View at Google Scholar
  35. C. W. Karpen, K. A. Pritchard Jr., A. J. Merola, and R. V. Panganamala, “Alterations of the prostacyclin-thromboxane ratio in streptozotocin induced diabetic rats,” Prostaglandins and Medicine, vol. 8, no. 2, pp. 93–103, 1982. View at Google Scholar · View at Scopus
  36. D. Armstrong, N. Abdella, A. Salman, N. Miller, E. A. Rahman, and M. Bojancyzk, “Relationship of lipid peroxides to diabetic complications. Comparison with conventional laboratory tests,” Journal of Diabetes and its Complications, vol. 6, no. 2, pp. 116–122, 1992. View at Publisher · View at Google Scholar · View at Scopus
  37. M. E. Hartnett, R. D. Stratton, R. W. Browne, B. A. Rosner, R. J. Lanham, and D. Armstrong, “Serum markers of oxidative stress and severity of diabetic retinopathy,” Diabetes Care, vol. 23, no. 2, pp. 234–240, 2000. View at Google Scholar · View at Scopus