Ethyl Pyruvate Prevents Methyglyoxal-Induced Retinal Vascular Injury in Rats

Figure 3

Blood-retinal barrier breakdown. Retinal permeability was determined by the FITC-dextran technique. Representative photomicrographs of the retina from a saline-injected eye (a), a MGO-injected eye (b), and an EP-treated eye (c). Control retina showed no leakage of the tracer into the retina as evidenced by the clear delineation of retinal capillaries. MGO-injected eye demonstrated a widespread breakdown of their BRB with tracer leakage into the neural retina and a loss of delineation of the retinal capillaries. However, the treatment of EP significantly decreased retinal vascular permeability. (d) Quantitative analysis of the immunofluorescence intensity for FITC-dextran. The data are expressed as the means ± SE. (𝑛=8). ^∗𝑃<0.01 versus the control group, ^#𝑃<0.01 versus the MGO-injected group.

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