Review Article

Early Life Factors and Type 2 Diabetes Mellitus

Figure 2

The effect of low protein diet during pregnancy on postnatal cell. Low protein diet during pregnancy may lead to increased oxidative stress, fibrosis, decreased HNF4a expression, defected mitochondriogenesis, and mitochondria dysfunction, and increased cell differentiation instead of proliferation was found in cell of adult animal offspring, which may participate in -cell dysfunction and consequently increase the incidence of T2DM.
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