Figure 4: Decreased renal function in is exacerbated by uninephrectomy. (a) Compared to KK-a/a mice, blood urea nitrogen (BUN) is slightly elevated in and KK-a/a + Unx, though this difference is not statistically significant at later time points in the KK-a/a + Unx group. Uninephrectomy further elevates BUN in , with BUN increased by twofold, indicating mild uremia in + Unx animals. (b) Renal function, as measured by glomerular filtration rate (GFR), is reduced by 32% in + Unx mice compared to KK-a/a littermate controls ( ).