TY - JOUR
A2 - Mohammad, Ghulam
AU - Abu El-Asrar, Ahmed M.
AU - Nawaz, Mohd Imtiaz
AU - Kangave, Dustan
AU - Mairaj Siddiquei, Mohammed
AU - Geboes, Karel
PY - 2013
DA - 2013/03/10
TI - Angiogenic and Vasculogenic Factors in the Vitreous from Patients with Proliferative Diabetic Retinopathy
SP - 539658
VL - 2013
AB - This study was conducted to determine levels of angiogenic and endothelial progenitor cell mobilizing (vasculogenic) factors in vitreous fluid from proliferative diabetic retinopathy (PDR) patients and correlate their levels with clinical disease activity. Vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor-2 (sVEGFR-2), stem cell factor (SCF), soluble c-kit (s-kit), endothelial nitric oxide synthase (eNOS), and prostaglandin E2 (PGE2) levels were measured by ELISA in vitreous samples from 34 PDR and 15 nondiabetic patients. eNOS was not detected. VEGF, sVEGFR-2, SCF, and s-kit levels were significantly higher in PDR with active neovascularization compared with quiescent PDR and nondiabetic patients (P<0.001; 0.007; 0.001; <0.001, resp.). In contrast, PGE2 levels were significantly higher in nondiabetic patients compared with PDR patients (P<0.001). There were significant correlations between levels of sVEGFR-2 versus SCF (r=0.950, P<0.001), sVEGFR-2 versus s-kit (r=0.941, P<0.001), and SCF versus s-kit (r=0.970, P<0.001). Our findings suggest that upregulation of VEGF, sVEGFR-2, SCF, and s-kit supports the contributions of angiogenesis and vasculogenesis in pathogenesis of PDR.
SN - 2314-6745
UR - https://doi.org/10.1155/2013/539658
DO - 10.1155/2013/539658
JF - Journal of Diabetes Research
PB - Hindawi Publishing Corporation
KW -
ER -