The Role of Uncoupling Proteins in Diabetes Mellitus

Figure 1

The mechanisms of ROS and DM development. Hyperglycemia may activate ROS generation through the mitochondrial and nonmitochondrial origins: NADPH oxidase, xanthine oxidase, uncoupled eNOS, lipoxygenase, cyclooxygenase, cytochrome P450 enzymes, and other hemoproteins. ROS can further cause β-cell damages and the development of DM and related complications.