Application of IgG-Derived Natural Treg Epitopes (IgG Tregitopes) to Antigen-Specific Tolerance Induction in a Murine Model of Type 1 Diabetes

Figure 4

Study 1—prevention of T1D in NOD mice using Tregitopes. Tregitopes in saline, given IP prior to onset of diabetes, had a moderately suppressive effect on development of diabetes in NOD mice. The incidence of diabetes for each arm is shown along the course of the study beginning at the first week that the mice received treatment. Arrows represent time points when Tregitope treatment was administered. Mice receiving vehicle alone (white circles) or irrelevant peptide (gray circles) had a higher incidence of diabetes at 29 weeks of age than mice receiving Tregitope treatment (black circles).